Corticotropin-like immunoreactivity in the brain and pituitary of three teleost species (goldfish, trout and eel)

Immunostaining of brain and pituitary sections of three teleost species (goldfish, trout and eel) with antisera to porcine and human ACTH 1-39 revealed the presence of an ACTH (adrenocorticotropic hormone)-like peptide in the ventral hypothalamus. Perikarya were localized in the rostral, median and...

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Bibliographic Details
Published in:Cell and tissue research 1990-10, Vol.262 (1), p.115-123
Main Authors: OLIVEREAU, M, OLIVEREAU, J. M
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - analysis
Animals
Biological and medical sciences
Brain - cytology
Brain Chemistry
Corticotropin-Releasing Hormone - analysis
Eels - metabolism
Female
Fundamental and applied biological sciences. Psychology
Goldfish - metabolism
Hormones and neuropeptides. Regulation
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Immunohistochemistry
Male
Pituitary Gland - chemistry
Pituitary Gland - cytology
Trout - metabolism
Vertebrates: endocrinology
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Summary:Immunostaining of brain and pituitary sections of three teleost species (goldfish, trout and eel) with antisera to porcine and human ACTH 1-39 revealed the presence of an ACTH (adrenocorticotropic hormone)-like peptide in the ventral hypothalamus. Perikarya were localized in the rostral, median and posterior portions of the nucleus lateralis tuberis (NLT); some were in contact with the cerebrospinal fluid. A dense network of immunoreactive (ir) fibers occurred in the peri-infundibular region and extended into the periventicular tissue, around the lateral and posterior recesses. Rostrally directed ir-fibers reached the telencephalon either ventrally or mediodorsally; some were observed in the olfactory lobe. In the mesencephalon, ir-fibers penetrated into the optic tectum of the goldfish. In the pituitary, both antisera intensely labeled rostral ACTH cells. Small groups of labeled cells were scattered in the rostral pars distalis and the proximal pars distalis. A gradient of activity was evident among ACTH cells: those located along the rostral neurohypophysis containing corticotropin-releasing factor nerve terminals were larger and often more marked than those farther away from the neural tissue. ACTH-like peptide in the brain may act as a neuromodulator, mainly in the NLT and the preoptic nucleus, and around the nuclei of the ventricular recesses containing serotonin and catecholamines.
ISSN:0302-766X
1432-0878
DOI:10.1007/bf00327752