A ratiometric fluorescent probe for imaging hydroxyl radicals in living cells

A novel fluorescent probe, the detection mechanism of which is based on the 'on-off' switching of a FRET triggered by the *OH-induced cleavage of a DNA strand, has been developed for the ratiometric imaging of *OH.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2004-03 (5), p.496-497
Main Authors: Soh, Nobuaki, Makihara, Koji, Sakoda, Emino, Imato, Toshihiko
Format: Article
Language:English
Subjects:
Cell Physiological Phenomena
Cells - chemistry
Cells - metabolism
Diagnostic Imaging
Fluorescent Dyes
Hydroxyl Radical - chemistry
Spectrometry, Fluorescence
Ultraviolet Rays
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Description
Summary:A novel fluorescent probe, the detection mechanism of which is based on the 'on-off' switching of a FRET triggered by the *OH-induced cleavage of a DNA strand, has been developed for the ratiometric imaging of *OH.
ISSN:1359-7345
1364-548X
DOI:10.1039/b314204c