Prognostic significance of morphological subtypes in canine malignant lymphomas during chemotherapy

The aim of this study was to determine the response of different morphological subtypes of canine lymphoma to a standardized therapeutic protocol. Diagnosis of lymphoma was based on cytohistological analysis and immunophenotyping with antibodies against CD3 and CD79a of an enlarged lymph node or an...

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Bibliographic Details
Published in:The veterinary journal (1997) 2004-03, Vol.167 (2), p.158-166
Main Authors: Ponce, Frédérique, Magnol, Jean-Pierre, Ledieu, David, Marchal, Thierry, Turinelli, Vanessa, Chalvet-Monfray, Karine, Fournel-Fleury, Corinne
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Chemotherapy
Classification
Dog
Dog Diseases - classification
Dog Diseases - drug therapy
Dog Diseases - epidemiology
Dog Diseases - mortality
Dogs
Female
France - epidemiology
Immunophenotyping - veterinary
Lymphoma
Lymphoma - classification
Lymphoma - epidemiology
Lymphoma - veterinary
Male
Oncology
Prognosis
Records as Topic - veterinary
Retrospective Studies
Survival Analysis
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Summary:The aim of this study was to determine the response of different morphological subtypes of canine lymphoma to a standardized therapeutic protocol. Diagnosis of lymphoma was based on cytohistological analysis and immunophenotyping with antibodies against CD3 and CD79a of an enlarged lymph node or an extranodal mass. Fifty-seven cases were classified according to the updated Kiel classification adapted to the canine species, into 24 B-cell lymphomas (20 centroblastic polymorphic and four Burkitt-type subtypes), and 33 T-cell lymphomas (10 pleomorphic mixed, 10 lymphoblastic, eight unclassifiable high grade plasmacytoid, and five small clear-cell subtypes). All dogs were clinically staged at diagnosis. The protocol used l-asparaginase, vincristine, cyclophosphamide, doxorubicin, and prednisone. First remission duration and overall survival time were evaluated. Although the T-cell phenotype was associated, on the whole, with a poor prognosis, as previously reported in veterinary and human medicine, the study showed significant prognostic differences between the B- and the T-cell subtypes of canine lymphoma and suggests that clinico-morphological characterization of the disease is justified in dogs, as in humans.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2003.10.009