Monocyte activation and disease activity in multiple sclerosis. A longitudinal analysis of serum MRP8/14 levels

In active multiple sclerosis (MS) lesions macrophages expressing myeloid related protein (MRP) 8/14 are present. The aim of this study was to determine whether serum levels of MRP8/14 complexes are related to disease activity in MS. In a longitudinal study of 16 relapsing remitting (RR) MS patients...

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Published in:Journal of neuroimmunology 2004-03, Vol.148 (1), p.172-177
Main Authors: Floris, Sarah, van der Goes, Annette, Killestein, Joep, Knol, Dirk L., Barkhof, Frederik, Polman, Chris H., Dijkstra, Christine D., de Vries, Helga E., Meilof, Jan F.
Format: Article
Language:English
Subjects:
Adult
Blood–brain barrier
Calgranulin A - blood
Calgranulin B - blood
Enzyme-Linked Immunosorbent Assay - methods
Female
Follow-Up Studies
Gadolinium DTPA - metabolism
Humans
Longitudinal
Longitudinal Studies
Macrophage
Magnetic Resonance Imaging - methods
Male
Middle Aged
Monocytes - metabolism
Monocytes - pathology
MRI
MRP8/14
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - blood
Multiple Sclerosis, Relapsing-Remitting - pathology
Receptors, Antigen, T-Cell, alpha-beta - immunology
Receptors, Antigen, T-Cell, alpha-beta - metabolism
Statistics, Nonparametric
Time Factors
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Summary:In active multiple sclerosis (MS) lesions macrophages expressing myeloid related protein (MRP) 8/14 are present. The aim of this study was to determine whether serum levels of MRP8/14 complexes are related to disease activity in MS. In a longitudinal study of 16 relapsing remitting (RR) MS patients that underwent monthly gadolinium diethylentriaminepenta acid (Gd-DTPA) magnetic resonance imaging (MRI), the relation between serum MRP8/14 levels and disease activity was investigated. Patients were participating in a monoclonal antibody study targeting a specific T cell population (Vβ5.2/5.3 + T-cells). In time, within patients large variations in serum MRP8/14 levels were observed. Serum MRP8/14 levels were not related to changes in clinical disease activity or increase in Gd-DTPA lesion enhancement. Neither did comparison of active (>1 relapse in follow-up period) with inactive (0–1 relapse) MS patients reveal any differences in MRP8/14 levels. Therefore, we conclude that although MRP8/14 expression is a good histopathological marker for monocyte activation, serum levels of these proteins do not correlate with disease activity in RR MS.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2003.11.005