Impaired T Helper 1 Function of Nonstructural Protein 3-Specific T Cells in Japanese Patients with Encephalitis with Neurological Sequelae

Japanese encephalitis virus (JEV) is the principal cause of viral encephalitis. The predominance of children among patients with encephalitis in areas where JEV is endemic that do not have immunization programs suggests that acquired immunity is critical in protecting adults against symptomatic JEV...

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Bibliographic Details
Published in:The Journal of infectious diseases 2004-03, Vol.189 (5), p.880-891
Main Authors: Kumar, Priti, Sulochana, Paramadevanapalli, Nirmala, Gejjehalli, Chandrashekar, Ramakrishnappa, Haridattatreya, Magandi, Satchidanandam, Vijaya
Format: Article
Language:English
Subjects:
Antibodies
Antibody Formation
Antigens
Antigens, Viral - immunology
Arboviral encephalitis
Arboviroses
Asian Continental Ancestry Group
Base Sequence
Biological and medical sciences
Cytokines - blood
Dengue
DNA Primers
Encephalitis
Encephalitis Virus, Japanese - genetics
Encephalitis Virus, Japanese - immunology
Encephalitis, Japanese - immunology
Fundamental and applied biological sciences. Psychology
Human immunodeficiency virus
Human viral diseases
Humans
Infections
Infectious diseases
Interferons
Japan
Japanese encephalitis virus
Japanese encephalitis viruses
Lymphocyte Activation
Medical sciences
Microbiology
RNA Helicases
Serine Endopeptidases
T lymphocytes
Th1 Cells - immunology
Tropical viral diseases
Vero cells
Viral diseases
Viral Nonstructural Proteins - genetics
Viral Nonstructural Proteins - immunology
Viruses
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Description
Summary:Japanese encephalitis virus (JEV) is the principal cause of viral encephalitis. The predominance of children among patients with encephalitis in areas where JEV is endemic that do not have immunization programs suggests that acquired immunity is critical in protecting adults against symptomatic JEV encephalitis. We characterized and compared the T cell response to nonstructural (NS) protein 3 between healthy individuals naturally exposed to JEV and patients in the convalescent phase of JEV encephalitis. The NS3 protein, used as a fusion to the 11-amino acid protein transduction domain of human immunodeficiency virus Tat, elicited CD4+ and T helper-dependent CD8+ T cell responses. The production of interferon (IFN)-γ by responding T cells was significantly higher in healthy donors than in patients, correlating strongly with acquired protective immunity to JEV. Furthermore, a striking inverse association between IFN-γ levels and the severity of postencephalitic sequelae in patients implicated a role of IFN-γ in recovery.
ISSN:0022-1899
1537-6613
DOI:10.1086/381768