Synthesis and biological evaluation of thiophene [3,2-b] pyrrole derivatives as potential anti-inflammatory agents

A series of thiophene [3,2-b] pyrrole derivatives were synthesized and evaluated their abilities to inhibit anti-inflammatory activity. In this series, substituent effects at the N-1, 2 and 5 positions of thiophene [3,2-b] pyrrole were examined. The results obtained are compared to those previously...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2004-03, Vol.12 (5), p.1221-1230
Main Authors: RAJENDER KUMAR, P, RAJU, S, SATISH GOUD, P, SAILAJA, M, SARMA, M. R, OM REDDY, G, PREM KUMAR, M, KRISHNA REDDY, V. V. R. M, SURESH, T, HEGDE, Pragathi
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Edema - chemically induced
Edema - prevention & control
Female
Male
Medical sciences
Pharmacology. Drug treatments
Piroxicam - analogs & derivatives
Piroxicam - pharmacology
Pyrroles - chemical synthesis
Pyrroles - pharmacology
Rats
Rats, Wistar
Structure-Activity Relationship
Thiophenes - chemical synthesis
Thiophenes - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of thiophene [3,2-b] pyrrole derivatives were synthesized and evaluated their abilities to inhibit anti-inflammatory activity. In this series, substituent effects at the N-1, 2 and 5 positions of thiophene [3,2-b] pyrrole were examined. The results obtained are compared to those previously reported anti-inflammatory drugs like Tenidap sodium, Diclofenac sodium and Piroxicam. The results indicated the critical role of the group linked in the N-1 position and 2, 5 positions of thiophene [3,2-b] pyrrole with different functional groups.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2003.11.003