UV-visible spectral identification of the solution-phase and solid-phase permanganate oxidation reactions of thymine acetic acid

Solution-phase and solid-phase permanganate oxidation reactions of thymine acetic acid were investigated by spectroscopy. The spectral data showed the formation of a stable organomanganese intermediate, which was responsible for the rise in the absorbance at 420 nm. This result enables unambiguous i...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2004-03, Vol.14 (5), p.1313-1315
Main Authors: BUI, Chinh T, SAM, Lien A, COTTON, Richard G. H
Format: Article
Language:English
Subjects:
Acetic Acid - analysis
Acetic Acid - chemistry
Acetic Acid - metabolism
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Oxidation-Reduction - drug effects
Potassium Permanganate - analysis
Potassium Permanganate - chemistry
Potassium Permanganate - metabolism
Preparations and properties
Solutions
Spectrophotometry, Ultraviolet - methods
Thymine - analysis
Thymine - chemistry
Thymine - metabolism
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Summary:Solution-phase and solid-phase permanganate oxidation reactions of thymine acetic acid were investigated by spectroscopy. The spectral data showed the formation of a stable organomanganese intermediate, which was responsible for the rise in the absorbance at 420 nm. This result enables unambiguous interpretation of the absorbance change at 420 nm, as the intermediate permanganate ions could be isolated on the solid supports.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2003.12.070