l-Arginine erythrocyte transport in normal pregnant and preeclamptic women

Uptake of l-arginine by the cell via amino acid transporter systems is the first step for nitric oxide (NO) production. The current study aimed to assess the total l-arginine uptake in erythrocytes of normal pregnant and preeclamptic women. Twenty-one normal pregnant and 21 preeclamptic women were s...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2004-02, Vol.190 (2), p.468-471
Main Authors: Costa, Bartira Pinheiro da, Steibel, João P., Antonello, Ivan Carlos, Guimarães, Jorge Almeida, Figueiredo, Carlos E.Poli de
Format: Article
Language:English
Subjects:
Adult
Arginine - metabolism
Biological and medical sciences
Diseases of mother, fetus and pregnancy
Erythrocytes - metabolism
Female
Gynecology. Andrology. Obstetrics
Humans
Hypertension
Medical sciences
Membrane transporters
Nitric oxide
Pre-Eclampsia - metabolism
Pre-Eclampsia - physiopathology
Pregnancy
Pregnancy - metabolism
Pregnancy. Fetus. Placenta
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Summary:Uptake of l-arginine by the cell via amino acid transporter systems is the first step for nitric oxide (NO) production. The current study aimed to assess the total l-arginine uptake in erythrocytes of normal pregnant and preeclamptic women. Twenty-one normal pregnant and 21 preeclamptic women were studied. To measure total l-arginine uptake in erythrocytes, carbon 14 was used as a marker and Michaelis-Menten kinetic parameters (Vmax and Km) were evaluated. In preeclamptic women, there was a significant increase (P
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2003.08.042