Elevated levels of secretory immunoglobulin a (sIgA) in urinary tract infections

Urinary secretory IgA (sIgA), an immunoglobulin synthesized locally in mucosal surface is an important immunological defense in preventing bacterial adherence to periurethral epithelia and uroepithelia. Therefore attempts were made to measure secretory IgA in the urine of children with urinary tract...

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Bibliographic Details
Published in:Indian journal of pediatrics 2004, Vol.71 (1), p.37-40
Main Authors: DEO, Sudha S, VAIDYA, Avinash K
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Aged
Bacterial diseases
Bacterial diseases of the urinary system
Biological and medical sciences
Biomarkers - analysis
Case-Control Studies
Child
Child, Preschool
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Female
General aspects
Human bacterial diseases
Humans
Immunoglobulin A, Secretory - analysis
Incidence
Infectious diseases
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Prognosis
Reference Values
Sensitivity and Specificity
Severity of Illness Index
Sex Distribution
Urinalysis
Urinary system involvement in other diseases. Miscellaneous
Urinary Tract Infections - diagnosis
Urinary Tract Infections - epidemiology
Urinary Tract Infections - urine
Urinary tract. Prostate gland
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Summary:Urinary secretory IgA (sIgA), an immunoglobulin synthesized locally in mucosal surface is an important immunological defense in preventing bacterial adherence to periurethral epithelia and uroepithelia. Therefore attempts were made to measure secretory IgA in the urine of children with urinary tract infections (UTI), by using sIgA specific ELISA. Fresh or unprocessed urine samples from healthy donors (children and adults N=10 each), 68 children and 17 Adults with UTI were tested for the presence of sIgA. The level of sIgA in 10 healthy normal children was 2.7 +/- 0.94 ug/ml and that in 10 healthy adults was 5.2 +/- 0.73 ug/ml. Children with UTI showed highly elevated levels of sIgA amounting to 279 +/- 80 ug/ml (p
ISSN:0019-5456
0973-7693
DOI:10.1007/BF02725654