Insulin-like growth factors and thecal-granulosa-cell function

Insulin-like growth factors (IGFs) belong to a family of low mol. wt, single chain plypeptides inducing growth promotion and insulin-like metabolism effects and regulating both cell replication and differentiation. Recent studies in laboratory animals suggest that IGFs play an important role as intr...

Full description

Saved in:
Bibliographic Details
Published in:Human reproduction (Oxford) 1990-10, Vol.5 (7), p.785-799
Main Authors: Geisthovel, Franz, Moretti-Rojas, Ines, Rojas, Francisco J., Asch, Ricardo H.
Format: Article
Language:English
Subjects:
Androgens - biosynthesis
Animals
Biological and medical sciences
Carrier Proteins - physiology
Female
Female genital diseases
folliculogenesis
Granulosa Cells - physiology
Growth Hormone - therapeutic use
Gynecology. Andrology. Obstetrics
Humans
IGF
Infertility, Female - drug therapy
Insulin-Like Growth Factor Binding Proteins
Medical sciences
Non tumoral diseases
ovarian control
Receptors, Cell Surface - physiology
Receptors, Somatomedin
reproductive disorders
Somatomedins - physiology
Theca Cells - physiology
thecal-granulosa cell
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Insulin-like growth factors (IGFs) belong to a family of low mol. wt, single chain plypeptides inducing growth promotion and insulin-like metabolism effects and regulating both cell replication and differentiation. Recent studies in laboratory animals suggest that IGFs play an important role as intraovarian regulators in several mammalian species. Tbe purpose of this article was to review current concepts of interactions between the IGFs and the thecal-granulosa-cell function. To provide a basic understanding of these interactions, we have first analysed data concerning biosynthesis, biochemical structure, pharmacokinetics, degradation, binding proteins and receptors for IGFs. Then we have discussed the specific interactions between IGFs and theca-granulosa-cell regulation, and analysed the significance of the relationship to the pathophysiology of some endocrine and reproductive disorders, including hyperandrogenism and female infertility.
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a137185