The prognostic significance of peak ammonia levels in Reye syndrome

Reye syndrome is currently viewed as a specific disease entity distinguished from other causes of hepatic failure and encephalopathy on clinical and histologic grounds. A variety of therapeutic approaches, ranging from supportive management to invasive intracranial pressure monitoring and barbiturat...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1982-12, Vol.70 (6), p.997-1000
Main Authors: Fitzgerald, J F, Clark, J H, Angelides, A G, Wyllie, R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Ammonia - blood
Child
Child, Preschool
Female
Humans
Infant
Male
Prognosis
Reye Syndrome - blood
Reye Syndrome - mortality
Risk
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Summary:Reye syndrome is currently viewed as a specific disease entity distinguished from other causes of hepatic failure and encephalopathy on clinical and histologic grounds. A variety of therapeutic approaches, ranging from supportive management to invasive intracranial pressure monitoring and barbiturate-induced coma, have been used because of the wide spectrum of disease progression and severity. Early identification of factors predictive of a poor outcome would be of value in assessing the need for aggressive management. Based on a ten-year experience with 95 patients with Reye syndrome, we suggest that peak plasma ammonia levels are predictive of disease severity and patient survival.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.70.6.997