Simultaneous Expression of Globin Genes for Embryonic and Adult Hemoglobins during Mammalian Ontogeny

The dominant hemoglobin of the adult hamster was detected in yolk-sac erythroid cells, and its identity was confirmed by peptide mapping and by analysis of relevant peptides. Both the presence and active synthesis of two embryonic hemoglobins presumed to exist only in yolk-sac erythroid cells were d...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1982-12, Vol.218 (4578), p.1225-1227
Main Authors: Boussios, Thalia, Bertles, John F., Clegg, John B.
Format: Article
Language:English
Subjects:
Age Factors
Animal embryology
Animals
Blood
Cell lines
Cricetinae
Embryology
Embryos
Erythrocytes
Erythroid cells
Fetal Hemoglobin - genetics
Gels
Gene Expression Regulation
Globins - genetics
Hamsters
Hemoglobin
Hemoglobins
Liver
Liver - physiology
Ontogeny
Spleen
Spleen - physiology
Yolk Sac - physiology
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Summary:The dominant hemoglobin of the adult hamster was detected in yolk-sac erythroid cells, and its identity was confirmed by peptide mapping and by analysis of relevant peptides. Both the presence and active synthesis of two embryonic hemoglobins presumed to exist only in yolk-sac erythroid cells were detected in neonatal liver and spleen. Thus the time span of expression of both embryonic and adult globin genes during mammalian ontogeny may be considerably broader than presently believed.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6183746