Slipping pumps or proton leaks in oxidative phosphorylation: The local anesthetic bupivacaine causes slip in cytochrome c oxidase of mitochondria

Evidence is presented to show that the local anesthetic bupivacaine causes slip in the mitochondrial proton pump cytochrome c oxidase.

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Bibliographic Details
Published in:FEBS letters 1990-12, Vol.277 (1), p.131-133
Main Authors: van Dam, Karel, Shinohara, Yasuo, Unami, Akira, Yoshida, Kenji, Terada, Hiroshi
Format: Article
Language:English
Subjects:
Anilino Naphthalenesulfonates - pharmacology
Animals
Biological and medical sciences
Bupivacaine - pharmacology
Cell physiology
Electron Transport Complex IV - metabolism
Fundamental and applied biological sciences. Psychology
Hydrogen-Ion Concentration
Local anesthetic
Male
Mitochondria
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Molecular and cellular biology
Oxidative phosphorylation
Oxidative Phosphorylation - drug effects
Oxygen Consumption - drug effects
Proton pump
Proton-Translocating ATPases - metabolism
Rats
Rats, Inbred Strains
Uncoupling
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Description
Summary:Evidence is presented to show that the local anesthetic bupivacaine causes slip in the mitochondrial proton pump cytochrome c oxidase.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(90)80826-5