Acetyl-L-carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver

The effect of acetyl-L-carnitine on the quantity of the messenger RNA for the subunit I of cytoehrome oxidase in the liver mitochondria of hypothyroid rat was measured by Northern blot and solution hybridization. Three hours after pre-treatment of hypothyroid rat with acetyl-L-carnitine, the level o...

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Bibliographic Details
Published in:FEBS letters 1990-12, Vol.277 (1), p.191-193
Main Authors: Gadaleta, M.N., Petruzzella, V., Fracasso, F., Fernandez-Silva, P., Cantatore, P.
Format: Article
Language:English
Subjects:
Acetyl-L-carnitine
Acetylcarnitine - pharmacology
Animals
Biological and medical sciences
Cell physiology
Col mRNA, messenger RNA for the subunit I of cytochrome oxidase
DNA, Mitochondrial - metabolism
Electron Transport Complex IV - genetics
Fundamental and applied biological sciences. Psychology
Gene Expression
Hypothyroid rat liver
Hypothyroidism - enzymology
Hypothyroidism - genetics
Male
Mitochondria, Liver - physiology
Mitochondrial DNA transcription
Molecular and cellular biology
mt, mitochondrial
Nucleic Acid Hybridization
PTU, propylthiouracyi
Rats
Rats, Inbred Strains
T3, 3,3 '-5-triiodo-L-thyronine
Triiodothyronine - pharmacology
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Summary:The effect of acetyl-L-carnitine on the quantity of the messenger RNA for the subunit I of cytoehrome oxidase in the liver mitochondria of hypothyroid rat was measured by Northern blot and solution hybridization. Three hours after pre-treatment of hypothyroid rat with acetyl-L-carnitine, the level of the transcript increased strongly. This effect was also obtained when acetyl-L-carnitine was administered to T 3 pre-treated hypothyroid rats. These results add further evidence to the suggestion that acetyl-L-camitine is able to stimulate mitochondrial transcription under altered metabolic conditions.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(90)80841-6