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Bacterial Colonization of the Upper Respiratory Tract and Its Association with Acute Lower Respiratory Tract Infections in Highland Children of Papua New Guinea
Acute lower respiratory tract infection (ALRI) is the major cause of death among children in Papua New Guinea. This longitudinal study reports the bacteriologic findings for children observed in their hamlets. A total of 1,449 nasal swab specimens from 158 children
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| Published in: | Reviews of infectious diseases 1990-11, Vol.12, p.S1006-S1016 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | S1016 |
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| container_start_page | S1006 |
| container_title | Reviews of infectious diseases |
| container_volume | 12 |
| creator | Janet M. Montgomery Deborah Lehmann Smith, Tom Michael, Audrey Benetty Joseph Tony Lupiwa Christine Coakley Veronica Spooner Bronwyn Best Ian D. Riley Alpers, Michael P. |
| description | Acute lower respiratory tract infection (ALRI) is the major cause of death among children in Papua New Guinea. This longitudinal study reports the bacteriologic findings for children observed in their hamlets. A total of 1,449 nasal swab specimens from 158 children |
| format | article |
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Montgomery ; Deborah Lehmann ; Smith, Tom ; Michael, Audrey ; Benetty Joseph ; Tony Lupiwa ; Christine Coakley ; Veronica Spooner ; Bronwyn Best ; Ian D. Riley ; Alpers, Michael P.</creator><creatorcontrib>Janet M. Montgomery ; Deborah Lehmann ; Smith, Tom ; Michael, Audrey ; Benetty Joseph ; Tony Lupiwa ; Christine Coakley ; Veronica Spooner ; Bronwyn Best ; Ian D. Riley ; Alpers, Michael P.</creatorcontrib><description>Acute lower respiratory tract infection (ALRI) is the major cause of death among children in Papua New Guinea. This longitudinal study reports the bacteriologic findings for children observed in their hamlets. A total of 1,449 nasal swab specimens from 158 children <5 years of age who were studied intensively for 18 months were examined. Non-serotypable strains of Haemophilus influenzae were isolated from 91% of specimens, and serotypable strains were isolated from 35% (8% H. influenzae type b) of specimens. All children had acquired Streptococcus pneumoniae by the age of 3 months. The most frequently occurring serotypes of S. pneumoniae were 6, 19, and 23. Children more frequently carried invasive pneumococci during an episode of ALRI than when they were healthy. Also, children more frequently carried serotypable strains of H. influenzae during the 2 weeks preceding an episode of ALRI than when they were healthy. Between-children analyses showed that children who were susceptible to attacks of ALRI and those who were not susceptible had similar rates of carriage of bacteria.</description><identifier>ISSN: 0162-0886</identifier><identifier>PMID: 2270397</identifier><language>eng</language><publisher>United States: University of Chicago Press</publisher><subject>Age Factors ; Ampicillin - pharmacology ; Bacteria ; Blood ; Carrier State - microbiology ; Child, Preschool ; Children ; Chloramphenicol - pharmacology ; Diseases ; Haemophilus Infections - microbiology ; Haemophilus influenzae - classification ; Haemophilus influenzae - drug effects ; Haemophilus influenzae - isolation & purification ; Highlands ; Humans ; Infant ; Infant, Newborn ; Longitudinal Studies ; Morbidity ; Nasal Mucosa - microbiology ; Papua New Guinea ; Penicillin ; Penicillin Resistance ; Respiratory tract infections ; Respiratory Tract Infections - microbiology ; Role of Bacterial Pathogens in Acute Respiratory Tract Infections ; Seasons ; Serotyping ; Specimens ; Streptococcal Infections - microbiology ; Streptococcus pneumoniae ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - drug effects ; Streptococcus pneumoniae - isolation & purification</subject><ispartof>Reviews of infectious diseases, 1990-11, Vol.12, p.S1006-S1016</ispartof><rights>Copyright 1990 The University of Chicago</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4455741$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4455741$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2270397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janet M. Montgomery</creatorcontrib><creatorcontrib>Deborah Lehmann</creatorcontrib><creatorcontrib>Smith, Tom</creatorcontrib><creatorcontrib>Michael, Audrey</creatorcontrib><creatorcontrib>Benetty Joseph</creatorcontrib><creatorcontrib>Tony Lupiwa</creatorcontrib><creatorcontrib>Christine Coakley</creatorcontrib><creatorcontrib>Veronica Spooner</creatorcontrib><creatorcontrib>Bronwyn Best</creatorcontrib><creatorcontrib>Ian D. Riley</creatorcontrib><creatorcontrib>Alpers, Michael P.</creatorcontrib><title>Bacterial Colonization of the Upper Respiratory Tract and Its Association with Acute Lower Respiratory Tract Infections in Highland Children of Papua New Guinea</title><title>Reviews of infectious diseases</title><addtitle>Rev Infect Dis</addtitle><description>Acute lower respiratory tract infection (ALRI) is the major cause of death among children in Papua New Guinea. This longitudinal study reports the bacteriologic findings for children observed in their hamlets. A total of 1,449 nasal swab specimens from 158 children <5 years of age who were studied intensively for 18 months were examined. Non-serotypable strains of Haemophilus influenzae were isolated from 91% of specimens, and serotypable strains were isolated from 35% (8% H. influenzae type b) of specimens. All children had acquired Streptococcus pneumoniae by the age of 3 months. The most frequently occurring serotypes of S. pneumoniae were 6, 19, and 23. Children more frequently carried invasive pneumococci during an episode of ALRI than when they were healthy. Also, children more frequently carried serotypable strains of H. influenzae during the 2 weeks preceding an episode of ALRI than when they were healthy. Between-children analyses showed that children who were susceptible to attacks of ALRI and those who were not susceptible had similar rates of carriage of bacteria.</description><subject>Age Factors</subject><subject>Ampicillin - pharmacology</subject><subject>Bacteria</subject><subject>Blood</subject><subject>Carrier State - microbiology</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Chloramphenicol - pharmacology</subject><subject>Diseases</subject><subject>Haemophilus Infections - microbiology</subject><subject>Haemophilus influenzae - classification</subject><subject>Haemophilus influenzae - drug effects</subject><subject>Haemophilus influenzae - isolation & purification</subject><subject>Highlands</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Longitudinal Studies</subject><subject>Morbidity</subject><subject>Nasal Mucosa - microbiology</subject><subject>Papua New Guinea</subject><subject>Penicillin</subject><subject>Penicillin Resistance</subject><subject>Respiratory tract infections</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Role of Bacterial Pathogens in Acute Respiratory Tract Infections</subject><subject>Seasons</subject><subject>Serotyping</subject><subject>Specimens</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - classification</subject><subject>Streptococcus pneumoniae - drug effects</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><issn>0162-0886</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><recordid>eNptULtOwzAUzQAqpfAHIHlii-TEdhyPJYI2UgUItXPkODfEVRoH21FVvoZPJaUVE9MdzuuecxFMcZTEIU7T5Cq4dm6LMSOcJpNgEsccE8GnwfejVB6sli3KTGs6_SW9Nh0yNfINoE3fg0Xv4HptpTf2gNZ2FCDZVSj3Ds2dM0qfJHvtGzRXgwe0Mvt_ZXlXgzqSHdIdWuqPpj06ZY1uKwu_qW-yHyR6gT1aDLoDeRNc1rJ1cHu-s2Dz_LTOluHqdZFn81W4jZjwIQHOlSAqIWUJFUkFjkRJOcNYQZVUqgYQrCKiBsmiGggbR-GUMg4xpYIAmQUPJ9_ems8BnC922iloxwfBDK5IcYxTzOhIvD8Th3IHVdFbvZP2UJwnHfG7E751Y_M_eMxinEbkB0qzfaQ</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>Janet M. 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Montgomery</creatorcontrib><creatorcontrib>Deborah Lehmann</creatorcontrib><creatorcontrib>Smith, Tom</creatorcontrib><creatorcontrib>Michael, Audrey</creatorcontrib><creatorcontrib>Benetty Joseph</creatorcontrib><creatorcontrib>Tony Lupiwa</creatorcontrib><creatorcontrib>Christine Coakley</creatorcontrib><creatorcontrib>Veronica Spooner</creatorcontrib><creatorcontrib>Bronwyn Best</creatorcontrib><creatorcontrib>Ian D. Riley</creatorcontrib><creatorcontrib>Alpers, Michael P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Reviews of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janet M. Montgomery</au><au>Deborah Lehmann</au><au>Smith, Tom</au><au>Michael, Audrey</au><au>Benetty Joseph</au><au>Tony Lupiwa</au><au>Christine Coakley</au><au>Veronica Spooner</au><au>Bronwyn Best</au><au>Ian D. Riley</au><au>Alpers, Michael P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacterial Colonization of the Upper Respiratory Tract and Its Association with Acute Lower Respiratory Tract Infections in Highland Children of Papua New Guinea</atitle><jtitle>Reviews of infectious diseases</jtitle><addtitle>Rev Infect Dis</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>12</volume><spage>S1006</spage><epage>S1016</epage><pages>S1006-S1016</pages><issn>0162-0886</issn><abstract>Acute lower respiratory tract infection (ALRI) is the major cause of death among children in Papua New Guinea. This longitudinal study reports the bacteriologic findings for children observed in their hamlets. A total of 1,449 nasal swab specimens from 158 children <5 years of age who were studied intensively for 18 months were examined. Non-serotypable strains of Haemophilus influenzae were isolated from 91% of specimens, and serotypable strains were isolated from 35% (8% H. influenzae type b) of specimens. All children had acquired Streptococcus pneumoniae by the age of 3 months. The most frequently occurring serotypes of S. pneumoniae were 6, 19, and 23. Children more frequently carried invasive pneumococci during an episode of ALRI than when they were healthy. Also, children more frequently carried serotypable strains of H. influenzae during the 2 weeks preceding an episode of ALRI than when they were healthy. Between-children analyses showed that children who were susceptible to attacks of ALRI and those who were not susceptible had similar rates of carriage of bacteria.</abstract><cop>United States</cop><pub>University of Chicago Press</pub><pmid>2270397</pmid></addata></record> |
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| identifier | ISSN: 0162-0886 |
| ispartof | Reviews of infectious diseases, 1990-11, Vol.12, p.S1006-S1016 |
| issn | 0162-0886 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80208054 |
| source | JSTOR Archival Journals and Primary Sources Collection; Oxford University Press Archive |
| subjects | Age Factors Ampicillin - pharmacology Bacteria Blood Carrier State - microbiology Child, Preschool Children Chloramphenicol - pharmacology Diseases Haemophilus Infections - microbiology Haemophilus influenzae - classification Haemophilus influenzae - drug effects Haemophilus influenzae - isolation & purification Highlands Humans Infant Infant, Newborn Longitudinal Studies Morbidity Nasal Mucosa - microbiology Papua New Guinea Penicillin Penicillin Resistance Respiratory tract infections Respiratory Tract Infections - microbiology Role of Bacterial Pathogens in Acute Respiratory Tract Infections Seasons Serotyping Specimens Streptococcal Infections - microbiology Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - isolation & purification |
| title | Bacterial Colonization of the Upper Respiratory Tract and Its Association with Acute Lower Respiratory Tract Infections in Highland Children of Papua New Guinea |
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