Protective effect of protease inhibitors in influenza virus infected animals

Injection of protease inhibitors into mice and chickens infected with lethal doses of influenza virus prevented dissemination of virus in the host organism and had a marked protective effect. Possible mechanisms for the anti-influenza effect of protease inhibitors are discussed.

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Bibliographic Details
Published in:Archives of virology 1982-01, Vol.73 (3/4), p.263-272
Main Authors: Zhirnov, O.P, Ovcharenko, A.V, Bukrinskaya, A.G
Format: Article
Language:English
Subjects:
Aminocaproates - therapeutic use
Aminocaproic Acid - therapeutic use
Animals
Aprotinin - therapeutic use
Chickens
Influenza A virus
Influenza in Birds - drug therapy
influenza virus
Mice
Orthomyxoviridae Infections - drug therapy
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Description
Summary:Injection of protease inhibitors into mice and chickens infected with lethal doses of influenza virus prevented dissemination of virus in the host organism and had a marked protective effect. Possible mechanisms for the anti-influenza effect of protease inhibitors are discussed.
ISSN:0304-8608
1432-8798
DOI:10.1007/BF01318080