THE STRUCTURE OF PA48009: THE REVISED STRUCTURE OF DURAMYCIN

PA48009, a lanthionine-containing peptide antibiotic was isolated from the culture broth of Streptoverticillium griseoverticillatum PA-48009, and identified as duramycin. Determination of the structure using both Edman degradations and 2D NMR spectroscopy showed the need to revise the structure of d...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1990/11/25, Vol.43(11), pp.1421-1430
Main Authors: HAYASHI, FUMIAKI, NAGASHIMA, KAZUO, TERUI, YOSHIHIRO, KAWAMURA, YOSHIMI, MATSUMOTO, KOICHI, ITAZAKI, HIROSHI
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - metabolism
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Bacteriocins
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Hydrogen-Ion Concentration
Hydrolysis
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbiology
Molecular Sequence Data
Molecular Structure
Peptides - chemistry
Peptides - metabolism
Streptomycetaceae - metabolism
Temperature
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:PA48009, a lanthionine-containing peptide antibiotic was isolated from the culture broth of Streptoverticillium griseoverticillatum PA-48009, and identified as duramycin. Determination of the structure using both Edman degradations and 2D NMR spectroscopy showed the need to revise the structure of duramycin given in literature. Duramycin (PA48009) was different from lanthiopeptin (Ro 09-0198, cinnamycin) only by a Lys/Arg exchange at position 2.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.43.1421