Complicated Migraine Studied by Phosphorus Magnetic Resonance Spectroscopy

The brain and skeletal muscle of eight adult patients with migraine with prolonged auras or migraine strokes leaving a permanent hemianopic defect were studied by phosphorus magnetic resonance spectroscopy. Biochemical assays performed on muscle biopsy and platelets had revealed abnormal mitochondri...

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Bibliographic Details
Published in:Cephalalgia 1990-10, Vol.10 (5), p.263-272
Main Authors: Barbiroli, B, Montagna, P, Cortelli, P, Martinelli, P, Sacquegna, T, Zaniol, P, Lugaresi, E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain - pathology
Brain bioenergetics
energy metabolism
exercising human skeletal muscle
Female
Humans
impaired human brain energy metabolism
Magnetic Resonance Imaging - methods
Middle Aged
Migraine Disorders - diagnosis
Muscles - pathology
Phosphorus
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Summary:The brain and skeletal muscle of eight adult patients with migraine with prolonged auras or migraine strokes leaving a permanent hemianopic defect were studied by phosphorus magnetic resonance spectroscopy. Biochemical assays performed on muscle biopsy and platelets had revealed abnormal mitochondrial enzyme activities. Brain magnetic resonance spectroscopy showed an abnormally low phosphocreatine to inorganic phosphate ratio in all patients, apparently due to decreased phosphocreatine and increased inorganic phosphate contents. Muscle phosphorus magnetic resonance spectroscopy showed low recovery from exercise in seven patients. Three patients had an increased phosphocreatine/inorganic phosphate ratio at rest, and the exercise transfer characteristics were abnormal in four patients for relatively low levels of exercise. The mitochondrial metabolic defects present in platelets and muscle of complicated migraine patients are therefore also expressed in the brain.
ISSN:0333-1024
1468-2982
DOI:10.1046/j.1468-2982.1990.1005263.x