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Mapping regional cerebral vascular transit time by simultaneous determination of local cerebral blood flow and local cerebral blood volume

We developed a method for autoradiographic mapping of regional cerebral transit time (CTT) by simultaneously measuring local cerebral blood flow (LCBF) and local cerebral blood volume (LCBV). Previously described single-tracer techniques for determination of LCBF and LCBV were modified for dual-trac...

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Published in:	Metabolic brain disease 1990-09, Vol.5 (3), p.155-165
Main Authors:	LEAR, J. L, KASLIWAL, R, FEYERABEND, A
Format:	Article
Language:	English
Subjects:	Animals Autoradiography Biological and medical sciences Blood Flow Velocity Blood Volume Cerebrovascular Circulation Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Nervous system Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rats Rats, Inbred Strains Time Factors
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container_title	Metabolic brain disease
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creator	LEAR, J. L KASLIWAL, R FEYERABEND, A
description	We developed a method for autoradiographic mapping of regional cerebral transit time (CTT) by simultaneously measuring local cerebral blood flow (LCBF) and local cerebral blood volume (LCBV). Previously described single-tracer techniques for determination of LCBF and LCBV were modified for dual-tracer, 99mTc and 14C, autoradiography and used to create digital images of LCBF and LCBV from the same brain sections in a series of normal rats. The images were aligned and ratio images (LCBV/LCBF) were then generated which reflected CTT. Regional cerebral transit time was found to vary significantly through-out the brain in a pattern only partially related to that of blood flow. Such CTT heterogeneity could cause errors in implementation of kinetic models which assume uniform or monovariant distributions of vascular transit time.
doi_str_mv	10.1007/BF00999842
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Such CTT heterogeneity could cause errors in implementation of kinetic models which assume uniform or monovariant distributions of vascular transit time.</description><identifier>ISSN: 0885-7490</identifier><identifier>EISSN: 1573-7365</identifier><identifier>DOI: 10.1007/BF00999842</identifier><identifier>PMID: 2274001</identifier><identifier>CODEN: MBDIEE</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Animals ; Autoradiography ; Biological and medical sciences ; Blood Flow Velocity ; Blood Volume ; Cerebrovascular Circulation ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Nervous system ; Pathology. Cytology. Biochemistry. Spectrometry. 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L</creatorcontrib><creatorcontrib>KASLIWAL, R</creatorcontrib><creatorcontrib>FEYERABEND, A</creatorcontrib><title>Mapping regional cerebral vascular transit time by simultaneous determination of local cerebral blood flow and local cerebral blood volume</title><title>Metabolic brain disease</title><addtitle>Metab Brain Dis</addtitle><description>We developed a method for autoradiographic mapping of regional cerebral transit time (CTT) by simultaneously measuring local cerebral blood flow (LCBF) and local cerebral blood volume (LCBV). Previously described single-tracer techniques for determination of LCBF and LCBV were modified for dual-tracer, 99mTc and 14C, autoradiography and used to create digital images of LCBF and LCBV from the same brain sections in a series of normal rats. The images were aligned and ratio images (LCBV/LCBF) were then generated which reflected CTT. Regional cerebral transit time was found to vary significantly through-out the brain in a pattern only partially related to that of blood flow. Such CTT heterogeneity could cause errors in implementation of kinetic models which assume uniform or monovariant distributions of vascular transit time.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Blood Flow Velocity</subject><subject>Blood Volume</subject><subject>Cerebrovascular Circulation</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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subjects	Animals Autoradiography Biological and medical sciences Blood Flow Velocity Blood Volume Cerebrovascular Circulation Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Nervous system Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Rats Rats, Inbred Strains Time Factors
title	Mapping regional cerebral vascular transit time by simultaneous determination of local cerebral blood flow and local cerebral blood volume
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