The nitrogen-sparing effect of methionine sulphoxide and some other sulphur-containing amino acids

1. The nitrogen-sparing effect of methionine, methionine sulphoxide, homocystme, cystine and choline was studied in rats by determining daily N excretions during 5 d after changing from a high-protein diet to a protein-free diet, L-glutamic acid was used as a negative control. 2. L-, D- and DL-methi...

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Bibliographic Details
Published in:British journal of nutrition 1982-11, Vol.48 (3), p.565-570
Main Authors: Njaa, L. R., Aksnes, A.
Format: Article
Language:English
Subjects:
Amino Acids - metabolism
Animals
Choline - metabolism
cystine
Cystine - metabolism
Dietary Proteins - metabolism
Homocystine - metabolism
Male
methionine
Methionine - analogs & derivatives
Methionine - metabolism
Nitrogen - metabolism
Nitrogen - urine
Papers on General Nutrition
Rats
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Summary:1. The nitrogen-sparing effect of methionine, methionine sulphoxide, homocystme, cystine and choline was studied in rats by determining daily N excretions during 5 d after changing from a high-protein diet to a protein-free diet, L-glutamic acid was used as a negative control. 2. L-, D- and DL-methionine were equally active in sparing N. L-methionine sulphoxide, DL-homocystine and L-cystine were as active as L-methionine. D-methionine sulphoxide was slightly less active than L-methionine sulphoxide, Choline hydrogen tartrate was not different from the negative control. 3. It is concluded that in short-term experiments cystine is the key substance in the N-sparing effect.
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN19820141