Effects of riboflavin analogues and diuretics on the spontaneously hypertensive rat heart

The chronic treatment of spontaneously hypertensive rats (SHR) with 7,8-dimethyl-10-(3-chlorobenzyl) isoalloxazine [CBI], 7,8-diethyl-10-aminol isoalloxazine [DEAI], enduron (methyclothiazide) and amiloride were studied for their effects on blood pressure and cardiac contractile protein ATPase activ...

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Bibliographic Details
Published in:Basic research in cardiology 1990-09, Vol.85 (5), p.444-452
Main Authors: BHASKAR, M, TRACHEWSKY, D, STITH, R. D, REDDY, Y. S
Format: Article
Language:English
Subjects:
Actins - pharmacology
Adenosine Triphosphatases - metabolism
Amiloride - pharmacology
Animals
Antihypertensive agents
Biological and medical sciences
Calcium - pharmacology
Cardiovascular system
Diuretics - pharmacology
Flavins - pharmacology
Male
Medical sciences
Myofibrils - enzymology
Myosins - metabolism
Pharmacology. Drug treatments
Rats
Rats, Inbred SHR
Riboflavin - analogs & derivatives
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Summary:The chronic treatment of spontaneously hypertensive rats (SHR) with 7,8-dimethyl-10-(3-chlorobenzyl) isoalloxazine [CBI], 7,8-diethyl-10-aminol isoalloxazine [DEAI], enduron (methyclothiazide) and amiloride were studied for their effects on blood pressure and cardiac contractile protein ATPase activities. After 35 weeks of treatment all the above antihypertensive agents showed a decrease in blood pressure in the SHR (p less than 0.01). Chronic treatment with CBI, DEAI, enduron, and amiloride significantly improved the myofibrillar ATPase activity at all pCa2+ concentrations (p less than 0.01). Furthermore, CBI, DEAI, enduron, and amiloride drug treatments enhanced actin-activated myosin ATPase activity (p less than 0.01). The Ca2(+)-activated myosin ATPase activity was significantly elevated after treating with CBI and DEAI (p less than 0.01). These results suggest that the antihypertensive agents used in this study helped in reducing the blood pressure with a subsequent increase in myocardial contractile protein ATPase activity.
ISSN:0300-8428
1435-1803
DOI:10.1007/BF01931490