THE KAPURIMYCINS, NEW ANTITUMOR ANTIBIOTICS PRODUCED BY STREPTOMYCES: PHYSICO-CHEMICAL PROPERTIES AND STRUCTURE DETERMINATION

The kapurimycins A1, A2 and A3 were revealed to be new antitumor antibiotics with molecular formula of C27H26O9, C26H24O9 and C27H24O9, respectively. The structures of the kapurimycins were determined by NMR spectroscopic analysis. The kapurimycins are new class of polycyclic microbial metabolites h...

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Bibliographic Details
Published in:Journal of antibiotics 1990/12/25, Vol.43(12), pp.1519-1523
Main Authors: YOSHIDA, MAYUMI, HARA, MITSUNOBU, SAITOH, YUTAKA, SANO, HIROSHI
Format: Article
Language:English
Subjects:
Anthracenes - chemistry
Antibiotics (antibacterial agents, antifungal agents)
Antibiotics, Antineoplastic - chemistry
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Microbiology
Molecular Structure
Pyrones - chemistry
Solubility
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
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Summary:The kapurimycins A1, A2 and A3 were revealed to be new antitumor antibiotics with molecular formula of C27H26O9, C26H24O9 and C27H24O9, respectively. The structures of the kapurimycins were determined by NMR spectroscopic analysis. The kapurimycins are new class of polycyclic microbial metabolites having the tetrahydroanthra-γ-pyrone skeleton and the β, γ-unsaturated δ-keto carboxylic acid structure. The individual components of the kapurimycins differ from one another in the side chain at the pyrone ring of the molecule.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.43.1519