Hematogenous Candida vertebral osteomyelitis treated with ketoconazole

Candida vertebral osteomyelitis was diagnosed in a patient with systemic lupus erythematodes following X-ray evidence of osteomyelitis and the repeated culturing of Candida albicans from material obtained by needle biopsies from the third lumbar vertebra. The patient had been on glucocorticosteroids...

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Bibliographic Details
Published in:Infection 1982-09, Vol.10 (5), p.290-292
Main Authors: Dijkmans, B A, Koolen, M I, Mouton, R P, Falke, T H, van den Broek, P J, van der Meer, J W
Format: Article
Language:English
Subjects:
Adult
Candidiasis - diagnosis
Candidiasis - drug therapy
Female
Humans
Imidazoles - therapeutic use
Ketoconazole
Lumbar Vertebrae
Lupus Erythematosus, Systemic - complications
Osteomyelitis - drug therapy
Osteomyelitis - etiology
Piperazines - therapeutic use
Spondylitis - diagnosis
Spondylitis - drug therapy
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Summary:Candida vertebral osteomyelitis was diagnosed in a patient with systemic lupus erythematodes following X-ray evidence of osteomyelitis and the repeated culturing of Candida albicans from material obtained by needle biopsies from the third lumbar vertebra. The patient had been on glucocorticosteroids and parenteral nutrition six months previously. At that time, a yeast was cultured from the blood and the tip of the subclavian catheter which had been removed. After candida vertebral osteomyelitis was diagnosed, she was treated with ketoconazole for seven months. Recovery was impressive, as judged by the clinical and radiographic findings. At the time of writing this paper--12 months after the withdrawal of ketoconazole--the patient showed no signs of recurrence.
ISSN:0300-8126
1439-0973
DOI:10.1007/BF01640877