FUNDAMENTAL AND CLINICAL STUDIES ON CEFOTAXIME IN THE PERINATAL PERIOD

Fundamental and clinical studies on the perinatal use of cefotaxime (CTX, HR-756), a new cephalosporin antibiotic, were done, with the following results. 1.Following intravenous administration of 2 g of CTX, transport of CTX from maternal serum toumbilical cord serum and to amniotic fluid was found...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1982/07/25, Vol.35(7), pp.1877-1881
Main Authors: YASUDA, JINSUKE, YAMAMOTO, TAKAO, ITO, MASAFUMI, HONJO, HIDEO, OKADA, HIROJI, KANAO, MASAAKI
Format: Article
Language:Japanese
Subjects:
Amniotic Fluid - metabolism
Cefotaxime - administration & dosage
Cefotaxime - metabolism
Cefotaxime - therapeutic use
Drug Evaluation
Female
Fetus - metabolism
Humans
Infant, Newborn
Injections, Intravenous
Milk, Human - metabolism
Pregnancy
Puerperal Infection - drug therapy
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Summary:Fundamental and clinical studies on the perinatal use of cefotaxime (CTX, HR-756), a new cephalosporin antibiotic, were done, with the following results. 1.Following intravenous administration of 2 g of CTX, transport of CTX from maternal serum toumbilical cord serum and to amniotic fluid was found to be good.CTX was not transferred into mother's milk. 2.In clinical use, CTX was given to 16 pregnant patients with premature rupture of the membrane.It showed excellent efficacy in preventing perinatal infection. Five patients with perinatal infections were administered CTX, and in 4 patients CTX had good efficacy. No side effects were noted in any cases.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.35.1877