Microcirculation and Hemorheology in NIDDM Patients

The authors studied 10 patients with non-insulin-dependent diabetes mellitus and 5 controls matched for age, sex, blood lipids, and smoking habit. The two groups were also comparable for hemorheologic characteristics as evaluated by viscosimetry on whole blood, plasma and serum, erythrocyte filtrati...

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Bibliographic Details
Published in:Angiology 1990-12, Vol.41 (12), p.1053-1057
Main Authors: Catalano, Maria, Tomasini, Maurizio, Annoni, Massimo, Gherardi, Elia, Scandale, Giovanni, Galimberti, Paolo, Porro, Tomaso, Milanese, Franco, Libretti, Arnaldo
Format: Article
Language:English
Subjects:
Associated diseases and complications
Biological and medical sciences
Blood Viscosity
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Erythrocyte Aggregation
Erythrocyte Deformability
Female
Fingers
Humans
Male
Medical sciences
Microcirculation
Middle Aged
Renal Circulation
Retinal Vessels - physiopathology
Skin - physiopathology
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Summary:The authors studied 10 patients with non-insulin-dependent diabetes mellitus and 5 controls matched for age, sex, blood lipids, and smoking habit. The two groups were also comparable for hemorheologic characteristics as evaluated by viscosimetry on whole blood, plasma and serum, erythrocyte filtration and aggregation. The microcirculation was studied in the subjects of both groups by microalbuminuria determination, retinal fluorangiography, and capillaroscopic examination of the bulbar conjunctive and nail folds. None of the patients presented microalbuminuria values higher than the upper limit of normal (20mg/24h). Fluorangiographic alterations were observed in 4 patients, and all 10 pre sented capillaroscopic alterations at the bulbar conjunctiva (microaneurysms, erythrocyte aggregates) and nail folds (more frequently of the fingers than toes). Similar alterations were detected in controls. Thus these abnormalities seem independent of hemorheologic values.
ISSN:0003-3197
1940-1574
DOI:10.1177/000331979004101205