Effect of dantrolene pretreatment on heat stroke in sheep

Dantrolene is effective in the management of malignant hyperpyrexia. Due to the similarities of malignant hyperpyrexia and heat stroke, we have investigated the effect of dantrolene on heat stroke in sheep. Our study indicates that dantrolene pretreatment decreases the extent of heat stroke signs an...

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Bibliographic Details
Published in:Pharmacological research 1990-09, Vol.22 (5), p.565-572
Main Authors: Tayeb, Osama S., Marzouki, Zohair M.H.
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Animals
Aspartate Aminotransferases - blood
Biological and medical sciences
Body Temperature - drug effects
dantrolene
Dantrolene - therapeutic use
Electrolytes - blood
Heat Exhaustion - blood
Heat Exhaustion - prevention & control
heat stroke
hyperthermia
Male
Medical sciences
Muscle
Parathyroid Hormone - blood
Pharmacology. Drug treatments
Sheep
Thyroid Hormones - blood
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Summary:Dantrolene is effective in the management of malignant hyperpyrexia. Due to the similarities of malignant hyperpyrexia and heat stroke, we have investigated the effect of dantrolene on heat stroke in sheep. Our study indicates that dantrolene pretreatment decreases the extent of heat stroke signs and some of the induced changes in enzymes and hormones. These results indicate that dantrolene may be a valuable drug in the prophylaxis against heat stroke attack in susceptible individuals.
ISSN:1043-6618
1096-1186
DOI:10.1016/S1043-6618(05)80048-9