Regulation of Drosophila folylpolyglutamates during development

The polyglutamate status of reduced folates during the larval, pupal and adult stages of Drosophila melanogaster development was investigated. The chain length distribution is very similar and is predominantly pentaglutamate. Half-life estimates of the hydrolytic degradation to the monoglutamate sho...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 1990-09, Vol.97 (2), p.187-188
Main Authors: Duke, E.J. (University College Dublin, Dublin, Ireland), Priest, D.G
Format: Article
Language:English
Subjects:
ACIDE FOLIQUE
ACIDE GLUTAMIQUE
ACIDO FOLICO
ACIDO GLUTAMICO
ACTIVIDAD ENZIMATICA
ACTIVITE ENZYMATIQUE
Animals
BIOLOGICAL DEVELOPMENT
Cells, Cultured
DESARROLLO BIOLOGICO
DEVELOPPEMENT BIOLOGIQUE
Diptera
DROSOPHILA MELANOGASTER
Drosophila melanogaster - growth & development
Drosophila melanogaster - metabolism
Drosophilidae
ENZYMIC ACTIVITY
FOLIC ACID
Folic Acid - metabolism
GLUTAMIC ACID
HIDROLASAS
HYDROLASE
HYDROLASES
Hydrolysis
PENTAGLUTAMATE
POLYGLUTAMATE HYDROLASE
Polyglutamic Acid - metabolism
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Summary:The polyglutamate status of reduced folates during the larval, pupal and adult stages of Drosophila melanogaster development was investigated. The chain length distribution is very similar and is predominantly pentaglutamate. Half-life estimates of the hydrolytic degradation to the monoglutamate showed larva less than pupa less than adult. This raises the possibility that polyglutamate hydrolase may have a role in regulating the total intracellular reduced folate content of the different developmental stages.
ISSN:0300-8177
1573-4919
DOI:10.1007/BF00221061