Relationship between lactate arteriovenous gradient and tissue lactate content in subendocardial and subepicardial layers of the ischaemic in situ heart

Myocardial lactate content and simultaneous evolution of a lactate arteriovenous gradient associated with incomplete obstruction of the left coronary bed were studied in dog hearts. Samples of blood were taken from a peripheral artery and the coronary sinus; transmural samples of myocardial tissue w...

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Bibliographic Details
Published in:Cardiovascular research 1982-10, Vol.16 (10), p.552-558
Main Authors: MAKDESSI, SAMAR AL, ANDRIEU, JEAN L, CHAH, QUADIRI TIMOUR, TUDURI, ALINE J, FAUCON, GEORGES
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Glucose - metabolism
Cardiology. Vascular system
Coronary Circulation
Coronary Disease - blood
Coronary Disease - metabolism
Coronary Disease - physiopathology
Coronary heart disease
Dogs
Female
Glucose - metabolism
Heart
Lactates - blood
Lactates - metabolism
Male
Medical sciences
Myocardium - metabolism
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Summary:Myocardial lactate content and simultaneous evolution of a lactate arteriovenous gradient associated with incomplete obstruction of the left coronary bed were studied in dog hearts. Samples of blood were taken from a peripheral artery and the coronary sinus; transmural samples of myocardial tissue were obtained from the left ventricular wall by drill biopsy in animals under total cardiopulmonary by-pass. Lactate content was assessed in subendocardial and subepicardial layers separately. A 40 to 70% reduction in coronary flow induced a quick reduction and even an inversion of the positive lactate gradient while the tissue content, which was similar to the arterial content, rose considerably, chiefly in the subendocardial layer. Lactate accumulating in tissue was released into the blood approximately in proportion to the tissue concentration. The value of employing the lactate concentration difference between arterial blood and coronary sinus blood as an index of the severity and duration of myocardial ischaemia is discussed.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/16.10.552