Does translational ambiguity increase during cell differentiation?

Several observations made in the fungus Podospora anserina suggest that translational ambiguity may increase, and possibly must increase, at specific stages of the life cycle. Such changes in the properties of the translational apparatus seem to occur as well in the yeast S. cerevisiae and in the al...

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Bibliographic Details
Published in:FEBS letters 1982-11, Vol.149 (2), p.167-170
Main Author: Picard-Bennoun, Marguerite
Format: Article
Language:English
Subjects:
Ascomycota - genetics
Cell Differentiation
Chlamydomonas - genetics
Chlamydomonas reinhardtii
Lower eukaryotes
Podospora anserina
Protein Biosynthesis
Ribosomal mutants
Saccharomyces cerevisiae
Saccharomyces cerevisiae - genetics
Translational fidelity
Xylariales - genetics
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Summary:Several observations made in the fungus Podospora anserina suggest that translational ambiguity may increase, and possibly must increase, at specific stages of the life cycle. Such changes in the properties of the translational apparatus seem to occur as well in the yeast S. cerevisiae and in the alga C. reinhardii. A slight increase of the misreading level would allow readthrough or frameshifting necessary to synthesise regulatory proteins in low amount at key points of cellular differentiation.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(82)81094-6