Anti-imipramine antibodies recognize endogenous serotonin uptake and imipramine binding inhibitors

Calf brain and human platelet extracts purified by Bio-Gel P 2 column chromatography contained substances that inhibited serotonin uptake and 3H-imipramine binding. Some of these endogenous substances were also recognized by rabbit antibodies produced against imipramine. The data suggest the possibl...

Full description

Saved in:
Bibliographic Details
Published in:Psychiatry research 1990-11, Vol.34 (2), p.205-212
Main Authors: Tang, Siu Wa, Cheung, Siu, Strijewski, Achim, Chudzik, Jerzy, Helmeste, Daiga
Format: Article
Language:English
Subjects:
Animals
Anti-imipramine antibodies
Antibodies
Biological and medical sciences
Blood Platelets - metabolism
Carrier Proteins
Cattle
endogenous ligands
Frontal Lobe - metabolism
Humans
Imipramine - immunology
Imipramine - pharmacokinetics
Medical sciences
Miscellaneous
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Radioligand Assay
Receptors, Drug
Receptors, Neurotransmitter - antagonists & inhibitors
Receptors, Neurotransmitter - metabolism
Receptors, Serotonin - metabolism
Serotonin - blood
Serotonin Antagonists
serotonin uptake
Techniques and methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Calf brain and human platelet extracts purified by Bio-Gel P 2 column chromatography contained substances that inhibited serotonin uptake and 3H-imipramine binding. Some of these endogenous substances were also recognized by rabbit antibodies produced against imipramine. The data suggest the possible existence of endogenous serotonin uptake modulators, which may possess a partial molecular structure similar to that identified by the antibodies.
ISSN:0165-1781
1872-7123
DOI:10.1016/0165-1781(90)90020-6