In vivo distributions of some component fractions of Tc(NaBH 4)-HEDP mixtures separated by anion exchange high performance liquid chromatography

Anion exchange high performance liquid chromatography has been utilized to separate the component Tc-HEDP complexes of “carrier added” as well as “no carrier added” 99 m Tc(NaBH 4)-HEDP reaction mixtures. The chromatographically separated “carrier added” Tc-HEDP components exhibit distinctly differe...

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Bibliographic Details
Published in:The International journal of applied radiation and isotopes 1982-10, Vol.33 (10), p.907-915
Main Authors: Pinkerton, Thomas C., Ferguson, Debra L., Deutsch, Edward, Heineman, William R., Libson, Karen
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - diagnostic imaging
Borohydrides - isolation & purification
Borohydrides - metabolism
Chromatography, High Pressure Liquid - methods
Chromatography, Ion Exchange - methods
Etidronic Acid - isolation & purification
Etidronic Acid - metabolism
Female
Kidney - diagnostic imaging
Kinetics
Liver - diagnostic imaging
Muscles - diagnostic imaging
Organotechnetium Compounds
Radionuclide Imaging
Rats
Rats, Inbred Strains
Technetium - isolation & purification
Technetium - metabolism
Tissue Distribution
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Summary:Anion exchange high performance liquid chromatography has been utilized to separate the component Tc-HEDP complexes of “carrier added” as well as “no carrier added” 99 m Tc(NaBH 4)-HEDP reaction mixtures. The chromatographically separated “carrier added” Tc-HEDP components exhibit distinctly different biodistributions which are directly related to the chromatographic characteristics of the individual components. The Tc-HEDP complexes with shortest retention times, and therefore the lowest negative “charge density” have the maximum uptake on the bone, minimum uptake in the kidney, and fastest blood clearance.
ISSN:0020-708X
DOI:10.1016/0020-708X(82)90136-3