A comparison between intraperitoneal ciprofloxacin and intraperitoneal vancomycin and gentamicin in the treatment of peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD)

In a prospective, randomized, controlled trial in 40 patients, intraperitoneal ciprof-loxacin was shown to be as effective as the currently recommended regimen of intraperitoneal vancomycin and gentamicin for the treatment of CAPD peritonitis. There was one treatment failure in the dprofloxacin arm...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1990-12, Vol.26 (suppl-F), p.77-81
Main Authors: Friedland, J. S., Iveson, T. J., Fraise, A. P., Winearls, C. G., Selkon, J. B., Oliver, D. O.
Format: Article
Language:English
Subjects:
Adult
Aged
Ciprofloxacin - administration & dosage
Ciprofloxacin - therapeutic use
Female
Gentamicins - administration & dosage
Gentamicins - therapeutic use
Humans
Injections, Intraperitoneal
Male
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory - adverse effects
Peritonitis - drug therapy
Peritonitis - etiology
Vancomycin - administration & dosage
Vancomycin - therapeutic use
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Description
Summary:In a prospective, randomized, controlled trial in 40 patients, intraperitoneal ciprof-loxacin was shown to be as effective as the currently recommended regimen of intraperitoneal vancomycin and gentamicin for the treatment of CAPD peritonitis. There was one treatment failure in the dprofloxacin arm and four in the comparative arm. A single drug regimen is preferred by patients. The intraperitoneal route of administration of dprofloxacin therapy has advantages over the oral route.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/26.suppl_F.77