Isolation and characterization of DNA-binding peptides from the serum: inhibition of transcription and comparison with the tissue peptides

Small peptides highly active in inhibiting DNA transcription "in vitro" by eukaryotic and prokaryotic RNA polymerases and in inereasing the melting point of double stranded DNA can be isolated from the serum of various sources. Peptides with the same biological activity and with identical...

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Bibliographic Details
Published in:Molecular biology reports 1982-01, Vol.8 (4), p.217-223
Main Authors: Amici, D, Barra, D, Hillar, M, Murri, O, Cicconi, F, Gianfranceschi, G L
Format: Article
Language:English
Subjects:
Amino Acids - analysis
Animals
Cattle
Chromatography, Affinity
DNA Helicases - blood
DNA Helicases - isolation & purification
DNA-binding protein
DNA-Binding Proteins
DNA-Directed RNA Polymerases - metabolism
Humans
Kinetics
Liver - metabolism
Male
man
Molecular Weight
Organ Specificity
pigs
serum
Species Specificity
Spermatozoa - metabolism
Swine
Thymus Gland - metabolism
Transcription, Genetic - drug effects
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Summary:Small peptides highly active in inhibiting DNA transcription "in vitro" by eukaryotic and prokaryotic RNA polymerases and in inereasing the melting point of double stranded DNA can be isolated from the serum of various sources. Peptides with the same biological activity and with identical or very similar amino acid composition are linked to chromatin DNA of several tissues.
ISSN:0301-4851
1573-4978
DOI:10.1007/BF00776583