The neo-synovial membrane of patients with active rheumatoid arthritis at resynovectomy. Histomorphological and immunohistological evaluations

Neo-synovial membranes, which formed after "primary" synovectomy in 21 patients with rheumatoid arthritis (RA), were studied at resynovectomy. The clinical, histomorphological, and immunohistological data were compared with data derived from "primary" synovial membranes from RA a...

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Bibliographic Details
Published in:Rheumatology international 1990-01, Vol.10 (5), p.191-198
Main Authors: Saal, J G, Fritz, P, Maschek, B J, Mischlinski, A, Laschner, W
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - pathology
Arthritis, Rheumatoid - surgery
Female
Heparin - metabolism
Humans
Immunohistochemistry
Male
Middle Aged
Muramidase - metabolism
Osteoarthritis - metabolism
Osteoarthritis - pathology
Osteoarthritis - surgery
Radiography
Reoperation
Synovectomy
Synovial Membrane - diagnostic imaging
Synovial Membrane - metabolism
Synovial Membrane - pathology
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Summary:Neo-synovial membranes, which formed after "primary" synovectomy in 21 patients with rheumatoid arthritis (RA), were studied at resynovectomy. The clinical, histomorphological, and immunohistological data were compared with data derived from "primary" synovial membranes from RA and osteoarthritis (OA) patients. The clinical data suggest a less active rheumatoid inflammatory response after synovectomy. Histomorphologicaly, the synovitis in resynovectomized neosynovial membranes of RA revealed no qualitative differences when compared with synovitis in the "primary" synovium. However, the degree of the inflammatory rection evaluated by the different parameters was found to be distinctly lower. The immunohistological data correlated with these findings.
ISSN:0172-8172
1437-160X
DOI:10.1007/BF02274832