Intermittent ketoconazole therapy of chronic mucocutaneous candidiasis in childhood

We report the clinical and laboratory findings in two children with chronic mucocutaneous candidiasis (CMC) treated successfully with intermittent long-term ketoconazole therapy. Both had chronic infection of the nails, skin and mucous membranes with positive cultures for candida. Both were resistan...

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Bibliographic Details
Published in:European journal of pediatrics 1982-11, Vol.139 (3), p.176-180
Main Authors: Fanconi, S, Seger, R, Joller, P, Issler, C, Schär, G
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Antifungal Agents - administration & dosage
Antifungal Agents - therapeutic use
Candida
Candidiasis - drug therapy
Candidiasis, Chronic Mucocutaneous - drug therapy
Candidiasis, Chronic Mucocutaneous - immunology
Drug Administration Schedule
Female
Humans
Imidazoles - therapeutic use
Ketoconazole
Lymphocyte Activation
Male
Piperazines - therapeutic use
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Summary:We report the clinical and laboratory findings in two children with chronic mucocutaneous candidiasis (CMC) treated successfully with intermittent long-term ketoconazole therapy. Both had chronic infection of the nails, skin and mucous membranes with positive cultures for candida. Both were resistant to multiple local and systemic antifungal agents. After institution of ketoconazole therapy there was a dramatic improvement with clearing of the oral (one week), skin (two months) and nail lesions (5 months). After 8 months the drug was stopped and clinical remission persisted for 10 and 7 months respectively. Relapse of oral candidiasis was treated with a short course of ketoconazole (4-16 weeks) leading to complete healing of the lesions. Clinical improvement was not related to an amelioration in lymphocyte transformation. There was no change in the progressive deterioration of the lymphocyte responses to candida antigen which was probably due to persisting candida cell wall components (e.g. mannan).
ISSN:0340-6199
1432-1076
DOI:10.1007/BF01377351