Loprazolam (HR158) and flurazepam with ethanol compared on tests of psychomotor ability

1. Twelve healthy female volunteers were given either loprazolam 1 mg, flurazepam 15 mg or placebo in conjunction with ethanol for 3 consecutive nights in a double-blind crossover study with each subject acting as her own control. 2. Neither of the test compounds, in conjunction with ethanol, showed...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1982-01, Vol.23 (6), p.509-512
Main Authors: Hindmarch, I, Gudgeon, A C
Format: Article
Language:English
Subjects:
Adult
Anti-Anxiety Agents
Benzodiazepines
Benzodiazepinones - administration & dosage
Benzodiazepinones - pharmacology
Cognition - drug effects
Double-Blind Method
Ethanol - administration & dosage
Ethanol - pharmacology
Female
Flurazepam - administration & dosage
Flurazepam - pharmacology
Humans
Psychomotor Performance - drug effects
Reaction Time - drug effects
Sleep Stages - drug effects
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Summary:1. Twelve healthy female volunteers were given either loprazolam 1 mg, flurazepam 15 mg or placebo in conjunction with ethanol for 3 consecutive nights in a double-blind crossover study with each subject acting as her own control. 2. Neither of the test compounds, in conjunction with ethanol, showed any statistically significant impairment of performance on tests of psychomotor ability the morning following 3 nights administration. 3. Subjective evaluations of the ease of getting to sleep and the perceived quality of sleep were improved by both drugs in conjunction with ethanol. However, flurazepam with ethanol produced a greater impairment of subjects' ratings of early morning behaviour than either loprazolam or placebo taken with ethanol. 4. Subjective reports of sedation were more prevalent the morning following flurazepam and ethanol than those after loprazolam and ethanol and placebo and ethanol.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00637498