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Assessment of right and left ventricular volumes during upright exercise in normal men

Ventricular volumes were measured in 10 normal subjects by using two independent methods: the stroke volume was obtained by the Fick principle and the ejection fraction by multigated radionuclide angiography. Data were collected at rest in the supine and upright positions and during an upright exerc...

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Published in:	European heart journal 1982-12, Vol.3 (6), p.529-536
Main Authors:	WYNS, W., MELIN, J. A., VANBUTSELE, R. J., DE COSTER, P. M., STEELS, M., PIRET, L., DETRY, J.-M. R.
Format:	Article
Language:	English
Subjects:	Adult Cardiac Output ejection fraction Heart - diagnostic imaging Heart Function Tests - methods Heart Rate Humans Male maximal exercise multigated equilibrium Physical Exertion radionuclide angiography Radionuclide Imaging Reference Values Space life sciences Stroke Volume
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container_issue	6
container_start_page	529
container_title	European heart journal
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creator	WYNS, W. MELIN, J. A. VANBUTSELE, R. J. DE COSTER, P. M. STEELS, M. PIRET, L. DETRY, J.-M. R.
description	Ventricular volumes were measured in 10 normal subjects by using two independent methods: the stroke volume was obtained by the Fick principle and the ejection fraction by multigated radionuclide angiography. Data were collected at rest in the supine and upright positions and during an upright exercise test, which included three levels of increasing severity. The left and right ventricular end-diastolic volumes (EDV) were maximal in the supine posture (respectively 183 and 260 ml); at rest both were significantly lower in the upright position (158 and 220 ml). At maximal exercise, the ventricular end-diastolic volumes were similar (left EDV=147 ml) or slightly lower (right EDV= 178 ml) than at rest in the upright position. During upright exercise, the end-systolic volumes (ESV) gradually decreased (P
doi_str_mv	10.1093/oxfordjournals.eurheartj.a061348
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A. ; VANBUTSELE, R. J. ; DE COSTER, P. M. ; STEELS, M. ; PIRET, L. ; DETRY, J.-M. R.</creator><creatorcontrib>WYNS, W. ; MELIN, J. A. ; VANBUTSELE, R. J. ; DE COSTER, P. M. ; STEELS, M. ; PIRET, L. ; DETRY, J.-M. R.</creatorcontrib><description>Ventricular volumes were measured in 10 normal subjects by using two independent methods: the stroke volume was obtained by the Fick principle and the ejection fraction by multigated radionuclide angiography. Data were collected at rest in the supine and upright positions and during an upright exercise test, which included three levels of increasing severity. The left and right ventricular end-diastolic volumes (EDV) were maximal in the supine posture (respectively 183 and 260 ml); at rest both were significantly lower in the upright position (158 and 220 ml). At maximal exercise, the ventricular end-diastolic volumes were similar (left EDV=147 ml) or slightly lower (right EDV= 178 ml) than at rest in the upright position. During upright exercise, the end-systolic volumes (ESV) gradually decreased (P<0.001) from 56 to 34 ml (left ESV) and from 118 to 64 ml (right ESV); simultaneously, the left ventricular ejection fraction (EF) increased from 64 to 77% (P<0.001) and the right ventricular EF increased from 47 to 64% (P<0.001). Since during exercise in the upright position, the end-diastolic volumes are unchanged or tend to decrease, a Frank-Starling mechanism cannot be called upon; the cardiac response to upright exercise is thus mainly based on an increased venous return and on an increase in myocardial contractility reflected by the increase in ejection fraction and the decrease in end-systolic volumes. The methods used in the present study can provide reference values for the measurement of absolute ventricular volumes during exercise by gated equilibrium radionuclide angiography.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/oxfordjournals.eurheartj.a061348</identifier><identifier>PMID: 7160391</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Cardiac Output ; ejection fraction ; Heart - diagnostic imaging ; Heart Function Tests - methods ; Heart Rate ; Humans ; Male ; maximal exercise ; multigated equilibrium ; Physical Exertion ; radionuclide angiography ; Radionuclide Imaging ; Reference Values ; Space life sciences ; Stroke Volume</subject><ispartof>European heart journal, 1982-12, Vol.3 (6), p.529-536</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c364t-6f792743da164b19bdd12cd73021e1bb800f00eb06e15855d429ec6cef5173fa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7160391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WYNS, W.</creatorcontrib><creatorcontrib>MELIN, J. 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The left and right ventricular end-diastolic volumes (EDV) were maximal in the supine posture (respectively 183 and 260 ml); at rest both were significantly lower in the upright position (158 and 220 ml). At maximal exercise, the ventricular end-diastolic volumes were similar (left EDV=147 ml) or slightly lower (right EDV= 178 ml) than at rest in the upright position. During upright exercise, the end-systolic volumes (ESV) gradually decreased (P<0.001) from 56 to 34 ml (left ESV) and from 118 to 64 ml (right ESV); simultaneously, the left ventricular ejection fraction (EF) increased from 64 to 77% (P<0.001) and the right ventricular EF increased from 47 to 64% (P<0.001). Since during exercise in the upright position, the end-diastolic volumes are unchanged or tend to decrease, a Frank-Starling mechanism cannot be called upon; the cardiac response to upright exercise is thus mainly based on an increased venous return and on an increase in myocardial contractility reflected by the increase in ejection fraction and the decrease in end-systolic volumes. The methods used in the present study can provide reference values for the measurement of absolute ventricular volumes during exercise by gated equilibrium radionuclide angiography.</description><subject>Adult</subject><subject>Cardiac Output</subject><subject>ejection fraction</subject><subject>Heart - diagnostic imaging</subject><subject>Heart Function Tests - methods</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Male</subject><subject>maximal exercise</subject><subject>multigated equilibrium</subject><subject>Physical Exertion</subject><subject>radionuclide angiography</subject><subject>Radionuclide Imaging</subject><subject>Reference Values</subject><subject>Space life sciences</subject><subject>Stroke Volume</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><recordid>eNpVkE1LxDAQhoMoun78BCEn8dJ10jRpe1NEXUUQYRXxEtJmol3bRpNG1n9vZZcFTwPzvjwzPIScMpgyKPmZW1rnzcJF3-s2TDH6d9R-WEw1SMazYotMmEjTpJSZ2CYTYKVIpCxe9sh-CAsAKCSTu2Q3ZxJ4ySbk-SIEDKHDfqDOUt-8vQ9U94a2aAf6Pa59U8dWe_rt2thhoCb6pn-j8XPVxSX6uglIm572zne6pSPskOzY8UE8Ws8D8nR9Nb-cJfcPN7eXF_dJzWU2JNLmZZpn3Ggms4qVlTEsrU3OIWXIqqoAsABYgUQmCiFMlpZYyxqtYDm3mh-QkxX307uviGFQXRNqbFvdo4tBFZAWecn5WDxfFWvvQvBo1fh_p_2PYqD-1Kr_atVGrVqrHRHH61ux6tBsAGuXY56s8iYMuNzE2n8omfNcqNnLq3qFO5nNxbN65L-FoY-d</recordid><startdate>198212</startdate><enddate>198212</enddate><creator>WYNS, W.</creator><creator>MELIN, J. 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J.</creatorcontrib><creatorcontrib>DE COSTER, P. M.</creatorcontrib><creatorcontrib>STEELS, M.</creatorcontrib><creatorcontrib>PIRET, L.</creatorcontrib><creatorcontrib>DETRY, J.-M. R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WYNS, W.</au><au>MELIN, J. A.</au><au>VANBUTSELE, R. J.</au><au>DE COSTER, P. M.</au><au>STEELS, M.</au><au>PIRET, L.</au><au>DETRY, J.-M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of right and left ventricular volumes during upright exercise in normal men</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>1982-12</date><risdate>1982</risdate><volume>3</volume><issue>6</issue><spage>529</spage><epage>536</epage><pages>529-536</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Ventricular volumes were measured in 10 normal subjects by using two independent methods: the stroke volume was obtained by the Fick principle and the ejection fraction by multigated radionuclide angiography. Data were collected at rest in the supine and upright positions and during an upright exercise test, which included three levels of increasing severity. The left and right ventricular end-diastolic volumes (EDV) were maximal in the supine posture (respectively 183 and 260 ml); at rest both were significantly lower in the upright position (158 and 220 ml). At maximal exercise, the ventricular end-diastolic volumes were similar (left EDV=147 ml) or slightly lower (right EDV= 178 ml) than at rest in the upright position. During upright exercise, the end-systolic volumes (ESV) gradually decreased (P<0.001) from 56 to 34 ml (left ESV) and from 118 to 64 ml (right ESV); simultaneously, the left ventricular ejection fraction (EF) increased from 64 to 77% (P<0.001) and the right ventricular EF increased from 47 to 64% (P<0.001). Since during exercise in the upright position, the end-diastolic volumes are unchanged or tend to decrease, a Frank-Starling mechanism cannot be called upon; the cardiac response to upright exercise is thus mainly based on an increased venous return and on an increase in myocardial contractility reflected by the increase in ejection fraction and the decrease in end-systolic volumes. The methods used in the present study can provide reference values for the measurement of absolute ventricular volumes during exercise by gated equilibrium radionuclide angiography.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>7160391</pmid><doi>10.1093/oxfordjournals.eurheartj.a061348</doi><tpages>8</tpages></addata></record>
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source	Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025
subjects	Adult Cardiac Output ejection fraction Heart - diagnostic imaging Heart Function Tests - methods Heart Rate Humans Male maximal exercise multigated equilibrium Physical Exertion radionuclide angiography Radionuclide Imaging Reference Values Space life sciences Stroke Volume
title	Assessment of right and left ventricular volumes during upright exercise in normal men
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