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Studies on the Metabolism of Unsaturated Fatty Acids. XI. Alterations in the Activities of Enoyl-CoA Hydratase, 3-Hydroxyacyl-CoA Epimerase and 2,4-Dienyl-CoA Reductase in Rat Liver Mitochondria and Peroxisomes by Clofibrate

Alterations in the activities of enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, and 2,4-dienoyl-CoA reductase in rat liver mitochondria and peroxisomes caused by clofibrate were compared in order to clarify the metabolic pathways for unsaturated fatty acids. Our results suggest that there are two...

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Published in:	Journal of biochemistry (Tokyo) 1982, Vol.92 (6), p.2051-2054
Main Authors:	MIZUGAKI, Michinao, NISHIMAKI, Tomoko, YAMAMOTO, Hirotaka, SAGI, Mataichi, YAMANAKA, Hiroshi
Format:	Article
Language:	English
Subjects:	Animals Body Weight - drug effects Clofibrate - pharmacology Enoyl-CoA Hydratase - metabolism Fatty Acid Desaturases - metabolism Hydro-Lyases - metabolism Isomerases - metabolism Kinetics Male Microbodies - enzymology Mitochondria, Liver - enzymology Organ Size - drug effects Organoids - enzymology Racemases and Epimerases - metabolism Rats Rats, Inbred Strains
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container_issue	6
container_start_page	2051
container_title	Journal of biochemistry (Tokyo)
container_volume	92
creator	MIZUGAKI, Michinao NISHIMAKI, Tomoko YAMAMOTO, Hirotaka SAGI, Mataichi YAMANAKA, Hiroshi
description	Alterations in the activities of enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, and 2,4-dienoyl-CoA reductase in rat liver mitochondria and peroxisomes caused by clofibrate were compared in order to clarify the metabolic pathways for unsaturated fatty acids. Our results suggest that there are two pathways for fatty acids having (a) double bond(s) at the even-numbered carbon atom(s) both in mitochondria and in peroxisomes. One is the hydratase-epimerase participating pathways, and the other is the reductase participating pathway. It is considered that the former in mitochondria occurs mainly under normal conditions, and the latter becomes significant when the degradation of fatty acids is stimulated.
doi_str_mv	10.1093/oxfordjournals.jbchem.a134140
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XI. Alterations in the Activities of Enoyl-CoA Hydratase, 3-Hydroxyacyl-CoA Epimerase and 2,4-Dienyl-CoA Reductase in Rat Liver Mitochondria and Peroxisomes by Clofibrate</title><author>MIZUGAKI, Michinao ; NISHIMAKI, Tomoko ; YAMAMOTO, Hirotaka ; SAGI, Mataichi ; YAMANAKA, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i232t-804b08acd728709d69bf62a6a850585b739c4ebd3b88826293057d08846abc6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Clofibrate - pharmacology</topic><topic>Enoyl-CoA Hydratase - metabolism</topic><topic>Fatty Acid Desaturases - metabolism</topic><topic>Hydro-Lyases - metabolism</topic><topic>Isomerases - metabolism</topic><topic>Kinetics</topic><topic>Male</topic><topic>Microbodies - enzymology</topic><topic>Mitochondria, Liver - enzymology</topic><topic>Organ Size - drug effects</topic><topic>Organoids - enzymology</topic><topic>Racemases and Epimerases - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MIZUGAKI, Michinao</creatorcontrib><creatorcontrib>NISHIMAKI, Tomoko</creatorcontrib><creatorcontrib>YAMAMOTO, Hirotaka</creatorcontrib><creatorcontrib>SAGI, Mataichi</creatorcontrib><creatorcontrib>YAMANAKA, Hiroshi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biochemistry (Tokyo)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MIZUGAKI, Michinao</au><au>NISHIMAKI, Tomoko</au><au>YAMAMOTO, Hirotaka</au><au>SAGI, Mataichi</au><au>YAMANAKA, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on the Metabolism of Unsaturated Fatty Acids. 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It is considered that the former in mitochondria occurs mainly under normal conditions, and the latter becomes significant when the degradation of fatty acids is stimulated.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>7161276</pmid><doi>10.1093/oxfordjournals.jbchem.a134140</doi><tpages>4</tpages></addata></record>
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subjects	Animals Body Weight - drug effects Clofibrate - pharmacology Enoyl-CoA Hydratase - metabolism Fatty Acid Desaturases - metabolism Hydro-Lyases - metabolism Isomerases - metabolism Kinetics Male Microbodies - enzymology Mitochondria, Liver - enzymology Organ Size - drug effects Organoids - enzymology Racemases and Epimerases - metabolism Rats Rats, Inbred Strains
title	Studies on the Metabolism of Unsaturated Fatty Acids. XI. Alterations in the Activities of Enoyl-CoA Hydratase, 3-Hydroxyacyl-CoA Epimerase and 2,4-Dienyl-CoA Reductase in Rat Liver Mitochondria and Peroxisomes by Clofibrate
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