Trimethoprim, sulphamethoxazole, bacterial adhesion and polymorphonuclear leucocyte function

Culturing Escherichia coli, Proteus mirabilis, and Klebsiella pneunoniae in the presence of subinhibitory concentrations (1/4 MIC) of trimethoprim, sulphamethoxazole or their combination, resulted in reduced adherence of all the above strains. The number of phagocytosed bacteria pre-exposed to subin...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1990-12, Vol.26 (6), p.803-812
Main Authors: Emmanouilides, Cristos E., Lianou, Popi E., Bassaris, Haris P., Papvassiliou, John Th
Format: Article
Language:English
Subjects:
Bacterial Adhesion - drug effects
Chemotaxis, Leukocyte - drug effects
Epithelial Cells
Escherichia coli
Escherichia coli - drug effects
Gram-Negative Bacteria - drug effects
Humans
In Vitro Techniques
Klebsiella pneumoniae
Klebsiella pneumoniae - drug effects
Microbial Sensitivity Tests
Mouth Mucosa - cytology
Mouth Mucosa - drug effects
Neutrophils - drug effects
Phagocytosis - drug effects
Proteus mirabilis
Proteus mirabilis - drug effects
Sulfamethoxazole - pharmacology
Trimethoprim - pharmacology
Trimethoprim, Sulfamethoxazole Drug Combination - pharmacology
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Summary:Culturing Escherichia coli, Proteus mirabilis, and Klebsiella pneunoniae in the presence of subinhibitory concentrations (1/4 MIC) of trimethoprim, sulphamethoxazole or their combination, resulted in reduced adherence of all the above strains. The number of phagocytosed bacteria pre-exposed to subinhibitory concentrations of the above antibiotics was not significantly changed, but a significant increase of bactericidal activity of the polymorphonuclear leucocytes was observed. Furthermore, filtrates of K. pneumoniae and P. mirabilis grown in the presence of trimethoprim alone or in combination with sulphainethoxazole induced an increased chemotactic response of human polymorphonuclear leucocytes.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/26.6.803