The Metabolism of Erythropoietin in the Normal and Uraemic Rabbit

The metabolism of recombinant human erythropoietin (rHuEpo) labelled with 125I has been investigated in five normal and nine 5/6-nephrectomised rabbits. The plasma erythropoietin half-life was significantly prolonged at 5.1 ± 1.2 h (mean ± SD) in the 5/6-nephrectomised rabbits, compared to 3.0 ± 0.4...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1990, Vol.5 (10), p.855-859
Main Authors: Brown, J. H., Elder, G. Elizabeth, Lappin, T. R. J., Bridges, J. M., McGeown, Mary G.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chronic renal failure
Disease Models, Animal
Erythropoietin
Erythropoietin - blood
Female
Half-Life
In Vitro Techniques
Male
Medical sciences
Nephrectomy
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Pharmacokinetics
Rabbits
Renal failure
Uremia - blood
Uremia - etiology
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Summary:The metabolism of recombinant human erythropoietin (rHuEpo) labelled with 125I has been investigated in five normal and nine 5/6-nephrectomised rabbits. The plasma erythropoietin half-life was significantly prolonged at 5.1 ± 1.2 h (mean ± SD) in the 5/6-nephrectomised rabbits, compared to 3.0 ± 0.4 h in sham-operated controls (P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/5.10.855