Endocrine aging in CBA mice: Characterization of uterine cytosolic and nuclear sex steroid receptors

We examined the evidence of alterations with age in sex steroid hormone/receptor interaction in the uteri of CBA mice. The mean affinity for estrogens and progesterone that we observed in uterine cytosols and nuclei of old (16–18 months) mice were no different than those observed in young (4–8 month...

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Bibliographic Details
Published in:Experimental gerontology 1982, Vol.17 (6), p.417-423
Main Authors: Belisle, Serge, Beaudry, Catherine, Lehoux, Jean-Guy
Format: Article
Language:English
Subjects:
Aging
Animals
Cell Nucleus - physiology
Cytosol - physiology
Estrogens - physiology
Female
Menopause
Mice
Mice, Inbred CBA
Progesterone - physiology
Receptors, Estrogen - physiology
Receptors, Progesterone - physiology
Uterus - physiology
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Summary:We examined the evidence of alterations with age in sex steroid hormone/receptor interaction in the uteri of CBA mice. The mean affinity for estrogens and progesterone that we observed in uterine cytosols and nuclei of old (16–18 months) mice were no different than those observed in young (4–8 months) animals. Whereas the total number of unoccupied estrogenic receptor sites in old uteri did not differ significantly from that observed in uteri of young mice, aging was accompanied by a 3-fold and significant decrease in mean nuclear binding sites when standardized as mg of DNA ( p < 0.05). Contrary to estrogen receptors, aging uteri showed a 3-fold and significant decrease in the total number of uterine progesterone receptor concentration ( p < 0.05) which was manifested by a decrease of progesterone binding sites in both the cytosol and the nucleus. These results suggest that aging CBA mice present a profile of altered hormone-receptor interraction which is only partly dependent on ovarian steroids.
ISSN:0531-5565
1873-6815
DOI:10.1016/S0531-5565(82)80002-8