Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning

Study objective – The aim was to characterise reactive hyperaemia and endothelium dependent (ADP) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium. Design – The left anterior descending coronary artery was occluded 5-7 cm distal...

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Bibliographic Details
Published in:Cardiovascular research 1990-12, Vol.24 (12), p.998-1007
Main Authors: Kirkeböen, Knut Arvid, Aksnes, Gunnar, Ilebekk, Arnfinn
Format: Article
Language:English
Subjects:
adenosine
Adenosine - pharmacology
Adenosine Diphosphate - pharmacology
ADP
Animals
Biological and medical sciences
Blood Volume - physiology
Cardiology. Vascular system
Coronary Circulation - drug effects
Coronary Disease - physiopathology
Coronary heart disease
Dose-Response Relationship, Drug
endothelium dependent vasodilatation
endothelium independent vasodilatation
Endothelium, Vascular - physiology
Female
Heart
Ligation
Male
Medical sciences
myocardial ischaemia
myocardial stunning
pig
preconditioning
reactive hyperaemia
Swine
Time Factors
Vasodilation - drug effects
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Summary:Study objective – The aim was to characterise reactive hyperaemia and endothelium dependent (ADP) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium. Design – The left anterior descending coronary artery was occluded 5-7 cm distal from its origin for consecutive periods of 2, 2, 5, 10, and 2 min separated by 30 min of reperfusion. Coronary flow was continuously measured by Doppler flowmetry proximal to the occlusion site. ADP and adenosine were infused into the left coronary artery proximal to the flowprobe. Experimental material – 11 domestic pigs, weight 25-36 kg, were used. Measurements and main results – In the stunned myocardium maximal reactive hyperaemia after 2 min of ischaemia was preserved, whereas all other variables describing reactive hyperaemia were diminished: time to maximal hyperaemia by 40% (p
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/24.12.998