Suppression of one monoclonal immunoglobulin in the presence of another in multiple myeloma: Evidence for benign B‐cell neoplasia

The case of a 77‐year‐old man with two monoclonal proteins, IgG lambda and IgG kappa, is presented. The IgG kappa protein increased in concentration, and, after two years, overt multiple myeloma developed with anemia and suppression of polyclonal immunoglobulins. The IgG lambda protein at first rema...

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Bibliographic Details
Published in:Cancer 1983-03, Vol.51 (6), p.1097-1100
Main Author: Keshgegian, Albert A.
Format: Article
Language:English
Subjects:
Aged
B-Lymphocytes
Hemoglobins - analysis
Humans
Hypergammaglobulinemia - blood
Immunoelectrophoresis
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunoglobulin kappa-Chains - analysis
Immunoglobulin lambda-Chains - analysis
Immunoglobulin M - analysis
Immunoglobulins - analysis
Male
Multiple Myeloma - blood
Precancerous Conditions - blood
Time Factors
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Summary:The case of a 77‐year‐old man with two monoclonal proteins, IgG lambda and IgG kappa, is presented. The IgG kappa protein increased in concentration, and, after two years, overt multiple myeloma developed with anemia and suppression of polyclonal immunoglobulins. The IgG lambda protein at first remained constant, but disappeared when overt myeloma developed. The disappearance of the IgG lambda protein suggests suppression of one neoplastic immunoglobulin clone by another, more aggressive, clone. This indicates that idiopathic monoclonal gammopathy can result from a benign neoplasm of B‐cells that is responsive to regulatory factors and is not an early stage of myeloma.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19830315)51:6<1097::AID-CNCR2820510621>3.0.CO;2-W