Epstein‐barr virus, fatal infectious mononucleosis, and Hodgkin's disease in siblings

Epstein‐Barr virus (EBV) infection in a family resulted in a fatal disseminated heterophil negative infectious mononucleosis syndrome in a nine‐year‐old girl. This was followed closely by a similar disease process in her six‐year‐old brother which evolved over a one‐year period into Stage IIIB Hodgk...

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Bibliographic Details
Published in:Cancer 1983-02, Vol.51 (3), p.509-520
Main Authors: Veltri, Robert W., Shah, Shiela H., McClung, James E., Klingberg, William G., Sprinkle, Philip M.
Format: Article
Language:English
Subjects:
Adult
Antibodies, Viral - analysis
Child
Epstein-Barr virus
Female
Herpesvirus 4, Human
Hodgkin Disease - genetics
Hodgkin Disease - immunology
Humans
Immunoglobulins - analysis
Infectious Mononucleosis - genetics
Infectious Mononucleosis - immunology
Liver - pathology
Lymph Nodes - pathology
Lymphocytes - immunology
Lymphoma - genetics
Lymphoma - immunology
Male
Rosette Formation
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Summary:Epstein‐Barr virus (EBV) infection in a family resulted in a fatal disseminated heterophil negative infectious mononucleosis syndrome in a nine‐year‐old girl. This was followed closely by a similar disease process in her six‐year‐old brother which evolved over a one‐year period into Stage IIIB Hodgkin's disease. Finally, three years after the index EBV case in the daughter, the mother was diagnosed with a non‐Burkitt's‐type undifferentiated lymphoma that proved rapidly fatal. The EBV involvement in the sister and brother was well documented serologically and virologically. The pathologic diagnosis was established and confirmed by more than one pathologist. There was no obvious evidence for either a specific or general immune defect in any of the family members tested. The progression of the six‐year‐old boy's EBV infection from a benign, yet disseminated disease process into a histopathologically confirmed case of Hodgkin's disease offers a strong suggestion that this virus was not behaving solely as a passenger. Especially relevant is the fact that the boy never fully recovered from his EBV infection and essentially became persistently infected with the virus as evidenced by his EBV‐EA serology and virology results.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19830201)51:3<509::AID-CNCR2820510324>3.0.CO;2-B