Neoplastic angioendotheliomatosis: Histologic, immunohistochemical, and ultrastructural findings in two cases

Two cases of neoplastic angioendotheliomatosis are described. Both patients presented with subacute development of dementia punctuated by focal neurologic signs. Postmortem examination in both cases disclosed a vasculocentric distribution of neoplastic cells in many organs. Two characteristic histol...

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Bibliographic Details
Published in:Cancer 1983-03, Vol.51 (6), p.1107-1118
Main Authors: Fulling, Keith H., Gersell, Deborah J.
Format: Article
Language:English
Subjects:
Adrenal Glands - blood supply
Adrenal Glands - pathology
Antigens - analysis
Autopsy
Brain - blood supply
Brain - pathology
Endothelium - analysis
Endothelium - ultrastructure
Factor VIII - analysis
Factor VIII - immunology
Hemangioendothelioma - pathology
Hemangioendothelioma - ultrastructure
Histocytochemistry
Humans
Kidney Glomerulus - blood supply
Kidney Glomerulus - pathology
Liver - blood supply
Liver - pathology
Male
Microscopy, Electron
Middle Aged
Neoplasms - ultrastructure
Vascular Diseases - pathology
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Summary:Two cases of neoplastic angioendotheliomatosis are described. Both patients presented with subacute development of dementia punctuated by focal neurologic signs. Postmortem examination in both cases disclosed a vasculocentric distribution of neoplastic cells in many organs. Two characteristic histologic patterns were seen: (1) distension of vascular spaces by free‐floating, intraluminal cells and (2) asymmetric, subendothelial tumor growth. Intravascular tumor and secondary vascular changes were associated with microinfarcts in involved organs. Immunohistochemical localization of factor VIII‐related antigen in the neoplastic cells of one case provides evidence for their endothelial origin. The neoplastic cells in both cases exhibited similar but nonspecific ultrastructural features. In addition, dramatic fine structural changes including the acquisition of numerous pinocytotic vesicles and bundles of fine filaments with periodic densities were found in the non‐neoplastic endothelial cells.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19830315)51:6<1107::AID-CNCR2820510623>3.0.CO;2-W