Leukaemia of novel gastrointestinal T-lymphocyte population infected with HTLV-I

In a 72-year-old man with watery diarrhoea and leukocytosis the proliferation of abnormal cells was studied in specimens obtained by endoscopic biopsy of the gastrointestinal tract. Flow cytometry of leukaemia cells revealed a monoclonal expansion of "double-negative" (CD4-, CD8-) cells be...

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Bibliographic Details
Published in:The Lancet (British edition) 1991-01, Vol.337 (8733), p.76-77
Main Authors: Hattori, T., Asou, N., Suzushima, H., Takatsuki, K., Tanaka, K., Naito, K., Natori, H., Oizumi, K.
Format: Article
Language:English
Subjects:
Aged
AIDS/HIV
Antibodies, Monoclonal
Biological and medical sciences
Biopsy
CD4 antigen
CD4 Antigens - immunology
CD8 antigen
Cell proliferation
Colon, Sigmoid - immunology
Colon, Sigmoid - pathology
Deltaretrovirus - genetics
Diarrhea
DNA, Viral - analysis
Flow cytometry
Gastrointestinal system
Gastrointestinal tract
Hematologic and hematopoietic diseases
HTLV-I Antibodies - analysis
Humans
Leukemia
Leukemia-Lymphoma, Adult T-Cell - diagnosis
Leukemia-Lymphoma, Adult T-Cell - etiology
Leukemia-Lymphoma, Adult T-Cell - immunology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukocytosis
Lymphocytes
Lymphocytes T
Male
Medical sciences
Southern blotting
T cell receptors
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Summary:In a 72-year-old man with watery diarrhoea and leukocytosis the proliferation of abnormal cells was studied in specimens obtained by endoscopic biopsy of the gastrointestinal tract. Flow cytometry of leukaemia cells revealed a monoclonal expansion of "double-negative" (CD4-, CD8-) cells bearing T-cell receptor (TCR) αβ products. Southern blotting confirmed monoclonal integration of HTLV-I. A novel T-cell subset of double-negative TCR αβ cells in the gastrointestinal tract in adult man may be a target for HTLV-I infection.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(91)90737-A