Are Pressure-Volume Relations at End-Systole a Reflection of Left Ventricular Myocardial Contractility?

The pressure-volume relation at end-systole is reportedly altered by changes in contractility. To explore the potential of this ratio in man 185 subjects including 23 normals (Group I) were studied. In 35 patients of Group II (16 with mitral stenosis, 7 with atrial septal defect, and 12 with cor pul...

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Bibliographic Details
Published in:Angiology 1983-02, Vol.34 (2), p.137-148
Main Authors: Ahmed, S. Sultan, Regan, Timothy J.
Format: Article
Language:English
Subjects:
Blood Pressure
Cardiac Volume
Cardiomyopathies - physiopathology
Coronary Disease - physiopathology
Heart Diseases - physiopathology
Heart Ventricles - physiopathology
Hemodynamics
Humans
Myocardial Contraction
Stroke Volume
Systole
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Summary:The pressure-volume relation at end-systole is reportedly altered by changes in contractility. To explore the potential of this ratio in man 185 subjects including 23 normals (Group I) were studied. In 35 patients of Group II (16 with mitral stenosis, 7 with atrial septal defect, and 12 with cor pulmonale) ESP/ESV like an index of contractility measuring force-velocity-length rela tionship (Cy Ix) was insignificantly different from Group I (ESP/ESV and Cy Ix in I = 1.73 ± .31 mmHg/sec, 1.46 ± .09 cm/sec/cm vs 1.44 ± .10, 1.31 ± .05 in II respectively.) With significantly reduced Cy Ix (1.03 ± .04, P
ISSN:0003-3197
1940-1574
DOI:10.1177/000331978303400208