Different epitopes on the dendritic cell-associated NLDC-145 molecule during ontogeny

A monoclonal antibody, 6D2, is described that recognizes a different epitope on the NLDC-145 dendritic cell associated molecule in the mouse. During ontogeny the epitope appears on interdigitating cells in lymphoid organs only around birth, whereas the NLDC-145 antigen can be detected as early as da...

Full description

Saved in:
Bibliographic Details
Published in:Immunobiology (1979) 1990-11, Vol.181 (4-5), p.388-397
Main Authors: KRAAL, G, AVIS, L, WIJFFELS, J, HOEBEN, K, TER HART, H
Format: Article
Language:English
Subjects:
Animals
Antibodies, Monoclonal
Antigenic determinants, haptens, artificial antigens
Antigens
Antigens, Surface
Biological and medical sciences
Dendritic Cells - cytology
Dendritic Cells - immunology
Epithelial Cells
Epithelium - immunology
Epitopes
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunohistochemistry
Mice
Mice, Inbred BALB C
Molecular immunology
Thymus Gland - cytology
Thymus Gland - growth & development
Thymus Gland - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A monoclonal antibody, 6D2, is described that recognizes a different epitope on the NLDC-145 dendritic cell associated molecule in the mouse. During ontogeny the epitope appears on interdigitating cells in lymphoid organs only around birth, whereas the NLDC-145 antigen can be detected as early as day 16 of gestation. No differences can be observed in the expression of the two antigenic determinants on the epithelial cells of the thymus during ontogeny. Evidence is presented that the two antibodies recognize different epitopes on the same molecule.
ISSN:0171-2985
1878-3279
DOI:10.1016/S0171-2985(11)80507-3