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Metabolic Effects of Isradipine Versus Hydrochlorothiazide in Diabetes Mellitus

Most antihypertensive drugs have negative effects on metabolic control in diabetic patients. Calcium antagonists have been widely used in antihypertensive treatment of diabetics, although a possible influence on glucose tolerance, insulin secretion, and insulin action is unknown. Therefore, the effe...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1991-01, Vol.17 (1), p.15-21
Main Authors: Klauser, Renate, Prager, Rudolf, Gaube, Susanne, Gisinger, Christoph, Schnack, Christoph, Kiienburg, Elisabeth, Schernthaner, Guntram
Format: Article
Language:English
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Summary:Most antihypertensive drugs have negative effects on metabolic control in diabetic patients. Calcium antagonists have been widely used in antihypertensive treatment of diabetics, although a possible influence on glucose tolerance, insulin secretion, and insulin action is unknown. Therefore, the effect of the calcium antagonist isradipine on glucose tolerance and insulin secretion (75 g oral glucose tolerance test) and on peripheral and hepatic insulin action (euglycemic clamp) was evaluated in 11 type II diabetic patients. All patients were treated with placebo or isradipine for 8 weeks (double-blind, crossover design). A second group of six diabetic patients received a thiazide diuretic, hydrochlorothiazide, according to the same protocol. Systolic blood pressure was significantly lowered after isradipine and hydrochlorothiazide compared with placebo (127±3 versus 139±6 mm Hg and 129±4 versus 142±4, respectively, p
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.17.1.15