Cardiovascular Effects of Antihypertensive Polar and Neutral Renomedullary Lipids

Two antihypertensive lipids can be extracted from fresh renal medulla. One is polar (the antihypertensive polar renomedullary lipid, or APRL) and the other is nonpolar (the antihyper-tensive neutral renomedullary lipid, or ANRL). APRL and ANRL differ in their biologic activitiesAPRL in bolus intrave...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1983-03, Vol.5 (2 Suppl I), p.I-112-I-118
Main Authors: MUIRHEAD, E ERIC, FOLKOW, BJORN, BYERS, LAWRENCE W, DESIDERIO, DOMINIC M, THOREN, PETER, GOTHBERG, GUNNAR, DOW, ALAN W, BROOKS, BENNIE
Format: Article
Language:English
Subjects:
Animals
Blood Pressure - drug effects
Dose-Response Relationship, Drug
Heart Rate - drug effects
Hemodynamics - drug effects
Hypertension, Renal - blood
Kidney - innervation
Kinetics
Lipids - pharmacology
Rabbits
Renal Veins
Sympathetic Nervous System - drug effects
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Summary:Two antihypertensive lipids can be extracted from fresh renal medulla. One is polar (the antihypertensive polar renomedullary lipid, or APRL) and the other is nonpolar (the antihyper-tensive neutral renomedullary lipid, or ANRL). APRL and ANRL differ in their biologic activitiesAPRL in bolus intravenous injections causes a very rapid decline in the arterial pressure (AP) while ANRL, after a lag of 2 minutes, causes a slower decline in AP. APRL increases heart rate and sympathetic activity. ANRL decreases heart rate and sympathetic activity. ANRL appears to convert to APRL, under certain in vitro circumstances, suggesting that the structure of the two molecules is related. ANRL and APRL appear in the renal venous effluent after unclipping; biologically, ANRL seems dominant. The renal venous effluent of the undipped isolated kidney lowers the HR and sympathetic activity of the normal rat. Unclipping degranulates the renomedullary interstitial cells (RIC). The antihypertensive effect of unclipping appears due to the secretion of ANRL and APRL by the kidney. It is concluded that ANRL seems to be the antihypertensive hormone of the RIC.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.5.2_Pt_2.I112